{"id":"W4410804010","doi":"10.1200/jco.2025.43.16_suppl.6033","title":"Initial safety and efficacy of PDL1V (PF-08046054), a vedotin-based ADC targeting PD-L1, in combination with pembrolizumab in patients with recurrent or metastatic (R/M) HNSCC.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; McGill University Health Centre","funders":"","keywords":"Medicine; Pembrolizumab; Oncology; Internal medicine; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001057754,0.0007763458,0.001134315,0.0003537553,0.0004395516,0.0007664681,0.000541913,0.0009119756,0.001930149],"category_scores_gemma":[0.00127887,0.0003936613,0.0009176618,0.0003342818,0.0005798377,0.0006318743,0.0003434445,0.002621708,0.0006311192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001581782,"about_ca_system_score_gemma":0.001021988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001792391,"about_ca_topic_score_gemma":0.004048806,"domain_scores_codex":[0.9994616,0.000230477,0.00003357704,0.000110798,0.0000637023,0.00009981307],"domain_scores_gemma":[0.9994237,0.0001525998,0.0001098858,0.00005776755,0.00004506104,0.0002110743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3729505,0.04506939,0.03297625,0.0007474312,0.001109355,0.00162344,0.0009005391,0.005417307,0.1846267,0.0002970155,0.0101676,0.3441146],"study_design_scores_gemma":[0.1352106,0.7125348,0.09225737,0.0001025816,0.001094356,0.002066028,0.000153197,0.004073361,0.04063039,0.0003040848,0.01149806,0.00007518448],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935722,0.001571319,0.0004227905,0.0002998165,0.00003247686,0.0007621879,0.001067477,0.00008407597,0.002187635],"genre_scores_gemma":[0.9964823,0.0004453002,0.000442418,0.0002467637,0.00004003309,0.0003222225,0.001287506,0.00001852537,0.0007149815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001930149,"threshold_uncertainty_score":0.01147676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0502117729583029,"score_gpt":0.4221898160640512,"score_spread":0.3719780431057483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}