{"id":"W4410804220","doi":"10.1200/jco.2025.43.16_suppl.6013","title":"Long-term results of the randomized, phase 3 KEYNOTE-412 trial of pembrolizumab (pembro) or placebo (pbo) plus concurrent chemoradiotherapy (CRT) for unresected, locally advanced head and neck squamous cell carcinoma (LA HNSCC).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Pembrolizumab; Placebo; Chemoradiotherapy; Head and neck; Oncology; Internal medicine; Head and neck squamous-cell carcinoma; Head and neck cancer; Surgery; Overall survival; Radiation therapy; Cancer; Pathology; Immunotherapy; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004115302,0.0014006,0.001944524,0.0002685755,0.0006127339,0.001164461,0.0009650582,0.002542224,0.009469446],"category_scores_gemma":[0.003182579,0.0006565052,0.001711434,0.0003788269,0.001258335,0.0014307,0.0006088565,0.00322246,0.001812772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007868216,"about_ca_system_score_gemma":0.001123208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005615184,"about_ca_topic_score_gemma":0.001537258,"domain_scores_codex":[0.9984541,0.0009287981,0.00008703554,0.0002356372,0.0001057387,0.0001887529],"domain_scores_gemma":[0.9978281,0.000493554,0.0006990575,0.0002540433,0.0001596344,0.0005656542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.979448,0.004531489,0.0006959285,0.0003530902,0.0008664477,0.00003634507,0.0000425528,0.0003456578,0.003322256,0.00007006797,0.001613046,0.008675036],"study_design_scores_gemma":[0.9161282,0.07698898,0.004009984,0.00003534141,0.0007606518,0.00004679187,0.00001871388,0.0001867253,0.0005915274,0.000136445,0.001078292,0.00001839248],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786703,0.005234955,0.0008001049,0.0009396428,0.0005768719,0.004341129,0.004837077,0.000167372,0.004432554],"genre_scores_gemma":[0.9804786,0.001752456,0.001265549,0.001993259,0.0004694753,0.004422951,0.005307637,0.00004759604,0.004262445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009469446,"threshold_uncertainty_score":0.03167844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07645688324040456,"score_gpt":0.4672902182160047,"score_spread":0.3908333349756002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}