{"id":"W4410805121","doi":"10.1200/jco.2025.43.16_suppl.3503","title":"ctDNA-guided adjuvant chemotherapy escalation in stage III colon cancer: Primary analysis of the ctDNA-positive cohort from the randomized AGITG dynamic-III trial (intergroup study of AGITG and CCTG).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University of British Columbia","funders":"National Health and Medical Research Council; National Institutes of Health; Marcus Foundation","keywords":"Medicine; Oncology; Internal medicine; Colorectal cancer; Cohort; Adjuvant; Adjuvant chemotherapy; Chemotherapy; Stage (stratigraphy); Randomized controlled trial; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006127899,0.001111163,0.001699382,0.00037685,0.0004602219,0.001227863,0.0007091407,0.001110956,0.002396954],"category_scores_gemma":[0.004523948,0.000548108,0.002387631,0.0006261429,0.0007926822,0.0007318674,0.000840913,0.002440428,0.0006270118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009566584,"about_ca_system_score_gemma":0.001731805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001189459,"about_ca_topic_score_gemma":0.002766779,"domain_scores_codex":[0.9977296,0.001351173,0.000111671,0.0003813768,0.0001983287,0.0002279002],"domain_scores_gemma":[0.9962029,0.0009575003,0.000966292,0.0006217334,0.0002588884,0.0009926497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.942471,0.007137139,0.02809825,0.0004465892,0.003299873,0.00006882197,0.00008908407,0.0008910816,0.002304467,0.0001104997,0.003216483,0.0118668],"study_design_scores_gemma":[0.6226439,0.2287506,0.1292176,0.0001715583,0.007687562,0.0004035353,0.0001243828,0.002659096,0.002530698,0.0006287622,0.005084385,0.00009786682],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891052,0.002630487,0.0007361123,0.0003116386,0.0001232611,0.001841043,0.004043505,0.00004444016,0.001164361],"genre_scores_gemma":[0.9874572,0.0007558539,0.0008479799,0.0006814587,0.00021858,0.001762078,0.007265317,0.00003307245,0.0009784509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006127899,"threshold_uncertainty_score":0.03240776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02145202439219167,"score_gpt":0.3953650284881216,"score_spread":0.3739130040959299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}