{"id":"W4410805181","doi":"10.1200/jco.2025.43.16_suppl.tps1121","title":"IND.241: A Canadian Cancer Trials Group liquid-biopsy informed platform trial to evaluate treatment in CDK4/6-inhibitor resistant ER+/HER2- metastatic breast.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Queen's University; University Health Network; Ottawa Hospital; Health Sciences Centre; Sunnybrook Health Science Centre; Kingston Health Sciences Centre; Queen Elizabeth II Health Sciences Centre; Princess Margaret Cancer Centre; BC Cancer Agency; University of Toronto; Dalhousie University","funders":"","keywords":"Medicine; Metastatic breast cancer; Breast cancer; Oncology; Biopsy; Cancer; Internal medicine; Clinical trial; Gynecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.009419998,0.0003836335,0.004287417,0.001015739,0.00007929989,0.00002586772,0.0002929624,0.0004564254,0.0005690728],"category_scores_gemma":[0.009553965,0.0002588098,0.0009110048,0.0007154924,0.0001964678,0.0002371754,0.00005262121,0.0009421555,0.00001951345],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.005754888,"about_ca_system_score_gemma":0.0266577,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01639823,"about_ca_topic_score_gemma":0.2263902,"domain_scores_codex":[0.9913058,0.0009833917,0.005979748,0.0003898143,0.0006173035,0.00072399],"domain_scores_gemma":[0.9904537,0.005060117,0.002297908,0.0003794025,0.0006015721,0.001207284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.5895557,0.001621415,0.001247137,0.00006295146,0.001833906,0.0010525,0.0005148136,0.00009267985,0.0005044716,0.0002473529,0.00119951,0.4020676],"study_design_scores_gemma":[0.4048764,0.07099414,0.055032,0.001714936,0.00247053,0.0006091258,0.001135375,0.00005192878,0.0003566326,0.001842398,0.4604362,0.0004803818],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563384,0.001265834,0.0001542976,0.03298898,0.004915352,0.002487622,0.0001118514,0.00001863678,0.001718998],"genre_scores_gemma":[0.9774991,0.000838713,0.007859341,0.008845035,0.003317544,0.0003835981,0.00001492366,0.00005532047,0.001186381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4592367,"threshold_uncertainty_score":0.9999864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2041088173537816,"score_gpt":0.5357717868143332,"score_spread":0.3316629694605517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}