{"id":"W4410805186","doi":"10.1200/jco.2025.43.16_suppl.1004","title":"Phase I/Ib study of inavolisib (INAVO) alone and in combination with endocrine therapy ± palbociclib (PALBO) in patients (pts) with <i>PIK3CA</i> -mutated, hormone receptor–positive, HER2-negative locally advanced/metastatic breast cancer (HR+, HER2– LA/mBC): Analysis of hyperglycemia (HG) in prediabetic/obese pts.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; Roche (Canada)","funders":"","keywords":"Palbociclib; Medicine; Oncology; Metastatic breast cancer; Internal medicine; Endocrine system; Hormone receptor; Hormone; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001372124,0.0003805419,0.003385013,0.001185038,0.00002757689,0.000009043097,0.0002258918,0.0001914267,0.00002981858],"category_scores_gemma":[0.0005477302,0.0002738239,0.0001691169,0.002734101,0.000673908,0.0003828878,0.00006970946,0.001187567,2.113526e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000572339,"about_ca_system_score_gemma":0.001081896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009434153,"about_ca_topic_score_gemma":0.004932507,"domain_scores_codex":[0.994127,0.00122441,0.003079953,0.0004947055,0.0006787775,0.0003951254],"domain_scores_gemma":[0.9934455,0.002358609,0.002448517,0.0002943601,0.001251801,0.0002011996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1444443,0.03508443,0.6682966,0.0000796342,0.002405043,0.0003060143,0.001760701,0.003166059,0.0003698065,0.000007466504,0.000009867814,0.1440701],"study_design_scores_gemma":[0.1820636,0.04585724,0.766918,0.001064802,0.0009699552,0.00003121211,0.001992328,0.0004226421,0.0003489767,0.00009556067,0.00004963069,0.0001860817],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960058,0.00110258,0.0001740983,0.001123298,0.0001019812,0.001324293,0.00006945991,0.000007699936,0.00009080094],"genre_scores_gemma":[0.994792,0.002477025,0.002232972,0.0003117186,0.0000298676,0.00007489803,0.0000190965,0.00003640762,0.00002602095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.143884,"threshold_uncertainty_score":0.9999714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02080913549157357,"score_gpt":0.3941607146954801,"score_spread":0.3733515792039065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}