{"id":"W4410805186","doi":"10.1200/jco.2025.43.16_suppl.1004","title":"Phase I/Ib study of inavolisib (INAVO) alone and in combination with endocrine therapy ± palbociclib (PALBO) in patients (pts) with <i>PIK3CA</i> -mutated, hormone receptor–positive, HER2-negative locally advanced/metastatic breast cancer (HR+, HER2– LA/mBC): Analysis of hyperglycemia (HG) in prediabetic/obese pts.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; Roche (Canada)","funders":"","keywords":"Palbociclib; Medicine; Oncology; Metastatic breast cancer; Internal medicine; Endocrine system; Hormone receptor; Hormone; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001192416,0.001529756,0.002181036,0.0006092794,0.0003942673,0.001626061,0.001176224,0.001289847,0.006400366],"category_scores_gemma":[0.0008156974,0.0008512018,0.001873137,0.0006674509,0.0009227369,0.001016841,0.0004459794,0.004298517,0.00160038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001127199,"about_ca_system_score_gemma":0.002172292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001508156,"about_ca_topic_score_gemma":0.004274647,"domain_scores_codex":[0.9996732,0.0001166903,0.00001644554,0.00006462603,0.00003639134,0.00009262886],"domain_scores_gemma":[0.9993902,0.00006355636,0.0001048477,0.00004687005,0.00004028973,0.0003542155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8412456,0.07178552,0.003639539,0.0008264759,0.001526943,0.0001077967,0.000139812,0.001703144,0.01927902,0.0002658337,0.004272549,0.05520777],"study_design_scores_gemma":[0.6727519,0.3135585,0.006429481,0.00006698721,0.0007753933,0.000159392,0.00008860917,0.0006585144,0.001934621,0.0002561332,0.003287203,0.00003327563],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769601,0.004224586,0.0008338147,0.0007331756,0.000379683,0.006825527,0.003514923,0.0002260634,0.006302093],"genre_scores_gemma":[0.9685259,0.004986561,0.002303381,0.00189638,0.00029537,0.007147566,0.007454404,0.00008855701,0.007301995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006400366,"threshold_uncertainty_score":0.02141142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02080913549157357,"score_gpt":0.3941607146954801,"score_spread":0.3733515792039065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}