{"id":"W4410805272","doi":"10.1200/jco.2025.43.16_suppl.10007","title":"ONITT: A phase I study of nanoliposomal irinotecan with talazoparib or temozolomide in children and young adults with recurrent or refractory solid tumors.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Irinotecan; Temozolomide; Refractory (planetary science); Solid tumor; Oncology; Internal medicine; Phases of clinical research; Cancer; Chemotherapy; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001492445,0.001197162,0.001450837,0.0003175984,0.0002472084,0.0005575335,0.0006964401,0.0006935995,0.00262954],"category_scores_gemma":[0.0008266888,0.0004788839,0.0008798187,0.0003650981,0.0006414531,0.0005040658,0.000518408,0.00173405,0.0005260447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001409213,"about_ca_system_score_gemma":0.002882341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002813026,"about_ca_topic_score_gemma":0.005732961,"domain_scores_codex":[0.9995421,0.0002331117,0.00002281123,0.0000577485,0.00005030343,0.00009406507],"domain_scores_gemma":[0.9994312,0.00007634062,0.0001260679,0.00003211956,0.00002901694,0.000305216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6316001,0.08426976,0.02742588,0.001343416,0.001638896,0.0005801462,0.0004985366,0.005388705,0.06258985,0.0005767029,0.004496919,0.179591],"study_design_scores_gemma":[0.3285664,0.6227629,0.02887989,0.00008355523,0.0008412102,0.0008246148,0.0001114863,0.003111517,0.005720889,0.0002554088,0.008801665,0.00004043539],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916251,0.001722639,0.001022456,0.0003207617,0.00005142422,0.002974905,0.0008344178,0.00007062084,0.001377648],"genre_scores_gemma":[0.9834394,0.003198463,0.004115126,0.0005622688,0.00008091911,0.004351493,0.002150023,0.00003242859,0.002069903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002813026,"threshold_uncertainty_score":0.01022464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03372924563251851,"score_gpt":0.4115084532335546,"score_spread":0.3777792076010361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}