{"id":"W4410808631","doi":"10.1200/jco.2025.43.16_suppl.526","title":"Treatment-related neutropenia as a predictor of response to adjuvant palbociclib in the PALLAS trial (ABCSG-42/AFT-05/BIG-14-13/PrE0109).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Pfizer","keywords":"Palbociclib; Medicine; Adjuvant; Neutropenia; Oncology; Internal medicine; Chemotherapy; Cancer; Breast cancer; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"randomized_trial","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"randomized_trial","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003773753,0.0005954567,0.0007560758,0.0002464273,0.0002081937,0.0008788853,0.000612109,0.0005535787,0.002458629],"category_scores_gemma":[0.002769103,0.0002472402,0.001012521,0.000343681,0.0003001118,0.0006616574,0.0004906263,0.002211562,0.0002467666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006042937,"about_ca_system_score_gemma":0.001076555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009827324,"about_ca_topic_score_gemma":0.002602794,"domain_scores_codex":[0.999033,0.0006355234,0.00004018443,0.0001319815,0.00008800019,0.00007137041],"domain_scores_gemma":[0.9983772,0.0005310954,0.000522071,0.0000897875,0.00006704243,0.0004127819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6669511,0.003300153,0.2290723,0.001152153,0.003716754,0.0001465945,0.0001053361,0.00262049,0.002941727,0.0004466763,0.009953137,0.07959354],"study_design_scores_gemma":[0.1891764,0.09451976,0.675009,0.0004018022,0.005565975,0.0008465023,0.0002119228,0.01566868,0.001859864,0.002542903,0.01408474,0.000112353],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985386,0.006748812,0.0004378697,0.001043852,0.0001655527,0.0005394764,0.00300868,0.00004491078,0.00262482],"genre_scores_gemma":[0.9916528,0.0009262433,0.0006590392,0.0005164336,0.0002107782,0.0005263351,0.004405656,0.000009264809,0.001093481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003773753,"threshold_uncertainty_score":0.01995772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08376305800752132,"score_gpt":0.4768709556258369,"score_spread":0.3931078976183156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}