{"id":"W4410808919","doi":"10.1200/jco.2025.43.16_suppl.6574","title":"Safety and efficacy of bromodomain and extra-terminal (BET) inhibitor INCB057643 in patients (pts) with relapsed or refractory myelofibrosis (r/r-MF) and other advanced myeloid neoplasms: A phase (Ph) 1 study.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Incyte","keywords":"Medicine; Bromodomain; Myelofibrosis; Refractory (planetary science); Myeloid; Phases of clinical research; Internal medicine; Oncology; Cancer research; Clinical trial; Bone marrow; Epigenetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001174455,0.0007911657,0.001510862,0.0003229964,0.0003395157,0.0008625375,0.0004949275,0.001062435,0.002470752],"category_scores_gemma":[0.0007742968,0.0003994076,0.001187311,0.0004069568,0.0005071706,0.0006950175,0.0002680874,0.002242242,0.0008508482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007677228,"about_ca_system_score_gemma":0.001138838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000529692,"about_ca_topic_score_gemma":0.001772599,"domain_scores_codex":[0.9996762,0.0001505301,0.00002334245,0.00005537725,0.00003772146,0.00005672927],"domain_scores_gemma":[0.9994285,0.00008760204,0.0001575586,0.0000276314,0.00003104671,0.0002677362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6966163,0.0445761,0.03243177,0.001388662,0.002832241,0.0006799325,0.0004118682,0.003300433,0.05003516,0.0003096581,0.005307917,0.1621101],"study_design_scores_gemma":[0.4423997,0.4869586,0.05705662,0.00008905178,0.001491352,0.001008514,0.0001076496,0.001696463,0.004332576,0.0002700174,0.004540223,0.00004934246],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943817,0.002524707,0.000188882,0.0002842114,0.00004163141,0.0006152924,0.0007875044,0.00003692421,0.00113912],"genre_scores_gemma":[0.9946139,0.001256055,0.0005308083,0.0007124795,0.00009432705,0.0004758112,0.001372003,0.000009719864,0.000934776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002470752,"threshold_uncertainty_score":0.008265495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02431550600404669,"score_gpt":0.3728273287398614,"score_spread":0.3485118227358147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}