{"id":"W4410810717","doi":"10.1200/jco.2025.43.16_suppl.2632","title":"Validation of ENLIGHT, an AI predictor of immune checkpoint blockade (ICB) response and resistance, across the treatment span.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Queen's University; University Health Network","funders":"","keywords":"Medicine; Blockade; Immune checkpoint; Oncology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004793563,0.000625493,0.0004835635,0.0007111063,0.0001696736,0.0007744259,0.0004642606,0.0005380941,0.001245784],"category_scores_gemma":[0.005665853,0.0001616213,0.0004789864,0.0003696753,0.0002963674,0.0004864344,0.000651866,0.0008120102,0.0004759074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006101924,"about_ca_system_score_gemma":0.0006626933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001444544,"about_ca_topic_score_gemma":0.001459974,"domain_scores_codex":[0.9992828,0.0003066431,0.00004607213,0.0002033556,0.0001070884,0.00005402253],"domain_scores_gemma":[0.9979011,0.001099914,0.0003225549,0.0002480512,0.0002272424,0.0002011866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0262066,0.00217356,0.599995,0.0004389127,0.001356323,0.0002099673,0.0002374074,0.1773482,0.02667188,0.0007714895,0.01029759,0.1542931],"study_design_scores_gemma":[0.001586287,0.01016838,0.2134429,0.00007193583,0.0005670064,0.0006578321,0.0001814013,0.744841,0.01889881,0.001501579,0.008023847,0.00005894733],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779372,0.0009878896,0.01072743,0.0003457491,0.00004165211,0.0002648,0.007069385,0.0003869273,0.002238982],"genre_scores_gemma":[0.982611,0.0001313187,0.005542372,0.0001368301,0.0000236816,0.0001437242,0.01056906,0.00002969533,0.0008123736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004793563,"threshold_uncertainty_score":0.02535111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06131153850967042,"score_gpt":0.4603479341100242,"score_spread":0.3990363956003538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}