{"id":"W4410810983","doi":"10.1101/2025.05.27.656404","title":"Evidence for chronological diversification of spinal neuron subtypes by a shared sequence of transcription factors","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Clinical Research Institute","funders":"","keywords":"Diversification (marketing strategy); Biology; Transcription (linguistics); Transcription factor; Sequence (biology); Computational biology; Neuroscience; Genetics; Evolutionary biology; Business; Gene; Marketing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002010502,0.0002730743,0.0003202329,0.0001096566,0.00006340277,0.00002659088,0.000486497,0.0004587914,0.0000163394],"category_scores_gemma":[0.0006036311,0.0002927301,0.0002047847,0.0001517385,0.0001481672,0.00001826189,0.0001752417,0.0002280609,0.00000116048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009092207,"about_ca_system_score_gemma":0.0003629251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008958782,"about_ca_topic_score_gemma":0.000002980729,"domain_scores_codex":[0.9984087,0.00009270609,0.000432905,0.0006892204,0.000162579,0.0002139358],"domain_scores_gemma":[0.9981642,0.00004101206,0.000463229,0.0006928237,0.0005742513,0.00006443488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002444715,0.00009522084,0.003594492,0.0005886529,0.00008608103,3.510579e-7,0.00000503235,0.0000346434,0.9950116,0.00008283217,0.0002521829,0.000004405419],"study_design_scores_gemma":[0.0002195979,0.0003593476,0.04064531,0.0005883791,0.0001027767,5.39382e-9,0.000003512066,0.00008335572,0.9561457,0.000001403871,0.001618596,0.0002319981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980333,0.002493532,0.01390837,0.000119043,0.0004345826,0.0008797337,0.00179409,0.00003565814,0.000001932783],"genre_scores_gemma":[0.9968131,0.0006280384,0.002228966,0.00002455997,0.00007151406,0.0001911185,0.00001005095,0.00002185364,0.00001081614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03886592,"threshold_uncertainty_score":0.9999525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06237424497719763,"score_gpt":0.2924207941296017,"score_spread":0.2300465491524041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}