{"id":"W4410811564","doi":"10.1200/jco.2025.43.16_suppl.5058","title":"Substudy G of the Canadian cancer trials group (CCTG) IND.234: PC_BETS (V)—A circulating tumor DNA (ctDNA)–directed phase II study of carboplatin in patients (Pts) with previously treated metastatic castration-resistant prostate cancer (mCRPC).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Cancer Care Ontario; Jewish General Hospital; University Health Network; Ottawa Hospital; Princess Margaret Cancer Centre; University of British Columbia; Queen Elizabeth II Health Sciences Centre; Dalhousie University; London Health Sciences Centre; McMaster University; Western University; Juravinski Cancer Centre; McGill University","funders":"","keywords":"Carboplatin; Medicine; Circulating tumor DNA; Oncology; Internal medicine; Cancer; Cancer research; Chemotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003439728,0.00138221,0.001959138,0.0006527773,0.001205231,0.001151963,0.001255141,0.001980055,0.01024322],"category_scores_gemma":[0.003640343,0.0005271495,0.001896655,0.001553594,0.0004862937,0.0004208097,0.0005063636,0.002156278,0.001542539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005309097,"about_ca_system_score_gemma":0.009392231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1069797,"about_ca_topic_score_gemma":0.4015967,"domain_scores_codex":[0.9987066,0.0006712755,0.0000893211,0.0001196755,0.0002066695,0.0002064662],"domain_scores_gemma":[0.9983266,0.0003374667,0.000375023,0.0001607895,0.0002678581,0.0005322161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5350319,0.003236533,0.01180728,0.01000635,0.006610085,0.0003656226,0.0004061085,0.001537486,0.01058877,0.001733248,0.313606,0.1050706],"study_design_scores_gemma":[0.7289246,0.02768281,0.0808624,0.001685754,0.00618478,0.0003821652,0.000145895,0.0007656906,0.001722728,0.0009584908,0.1505754,0.0001092404],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4195827,0.04375167,0.002103649,0.01411744,0.005050725,0.1068653,0.320746,0.0007015832,0.08708086],"genre_scores_gemma":[0.6111343,0.0238112,0.008515822,0.02302094,0.002896033,0.08980227,0.1958706,0.0003663222,0.04458255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1069797,"threshold_uncertainty_score":0.212714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07230359489327531,"score_gpt":0.4236817310986155,"score_spread":0.3513781362053402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}