{"id":"W4410811576","doi":"10.1200/jco.2025.43.16_suppl.5059","title":"Phase 1b/2 KEYNOTE-365 cohort I: Pembrolizumab (pembro) plus carboplatin and etoposide chemotherapy (chemo) or chemo alone for metastatic neuroendocrine prostate cancer (NEPC).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital","funders":"","keywords":"Medicine; Carboplatin; Pembrolizumab; Chemotherapy; Etoposide; Docetaxel; Prostate cancer; Oncology; Cohort; Internal medicine; Cancer; Cisplatin; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002378541,0.001847366,0.001322225,0.0004369719,0.0006380603,0.001000475,0.001392895,0.001656475,0.01426432],"category_scores_gemma":[0.001241816,0.0006030219,0.001270556,0.0004885726,0.0007868137,0.0009603058,0.0007049288,0.00373213,0.002664607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001913996,"about_ca_system_score_gemma":0.00317578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001832788,"about_ca_topic_score_gemma":0.005469993,"domain_scores_codex":[0.9994984,0.0001992868,0.00002787321,0.0001146055,0.0000537794,0.0001061395],"domain_scores_gemma":[0.9991123,0.0000724714,0.0002105581,0.00009286798,0.00006645019,0.0004452484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8247417,0.04631838,0.007849214,0.001936659,0.001397338,0.0002448126,0.0003078688,0.001583906,0.02605665,0.0009731115,0.02965638,0.05893398],"study_design_scores_gemma":[0.7473989,0.2143889,0.01231399,0.0001676464,0.0006717604,0.0004035818,0.0001038474,0.0004895938,0.003303391,0.0006408709,0.02007962,0.00003784405],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9006075,0.005510303,0.002570731,0.002104548,0.0005068127,0.04347664,0.03572768,0.0003707569,0.009125061],"genre_scores_gemma":[0.8799533,0.005135503,0.01054939,0.005562791,0.0004615569,0.04190122,0.04090494,0.0001816892,0.01534966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01426432,"threshold_uncertainty_score":0.04771888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1147649734767556,"score_gpt":0.5275964723278566,"score_spread":0.4128314988511009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}