{"id":"W4410811627","doi":"10.1200/jco.2025.43.16_suppl.tps7563","title":"QUINTESSENTIAL: A multicenter phase 2 study evaluating the efficacy and safety of arlocabtagene autoleucel (arlo-cel) in triple- and quad-class exposed patients with relapsed or refractory multiple myeloma (RRMM).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Multiple myeloma; Refractory (planetary science); Lenalidomide; Oncology; Internal medicine; Phases of clinical research; Cancer research; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002199485,0.001072662,0.001253722,0.0003496377,0.0002952036,0.0009977069,0.0009709973,0.001188041,0.005022046],"category_scores_gemma":[0.0008972347,0.0004674844,0.001233451,0.0004196841,0.0008543602,0.0009166114,0.0004439671,0.002979024,0.001105916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000794758,"about_ca_system_score_gemma":0.001385892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001008297,"about_ca_topic_score_gemma":0.002509731,"domain_scores_codex":[0.9994085,0.0003016732,0.00002380695,0.0001138112,0.00006380799,0.00008830832],"domain_scores_gemma":[0.9992555,0.0001017371,0.0001448246,0.00007531849,0.00006551964,0.0003570695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7338507,0.06621886,0.01120447,0.001196324,0.002921925,0.0003020646,0.0004503964,0.002610622,0.0591095,0.0004132078,0.005951093,0.1157709],"study_design_scores_gemma":[0.5663422,0.4082029,0.01508691,0.0000406816,0.0007411504,0.0003149946,0.00007294077,0.0008913563,0.003190811,0.000182452,0.004901235,0.00003242424],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885217,0.003116963,0.0008343535,0.0006475681,0.0001452322,0.002325622,0.002247073,0.0001745737,0.00198692],"genre_scores_gemma":[0.9875405,0.001427733,0.001608873,0.001117334,0.0001176012,0.001790299,0.00333177,0.00004493987,0.003020924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005022046,"threshold_uncertainty_score":0.0168004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1160809590072358,"score_gpt":0.493371956361664,"score_spread":0.3772909973544282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}