{"id":"W4410811842","doi":"10.1200/jco.2025.43.16_suppl.5002","title":"Prognostic significance of PSA>0.2 after 6-12 months treatment for metastatic hormone-sensitive prostate cancer (mHSPC) intensified by androgen-receptor pathway inhibitors (ARPI): A multinational real-world analysis of the IRONMAN registry.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre; University of British Columbia; Ottawa Hospital","funders":"Movember Foundation","keywords":"Medicine; Prostate cancer; Androgen receptor; Oncology; Androgen deprivation therapy; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001665458,0.0002059214,0.000322633,0.0002747961,0.0002136644,0.0004584661,0.0004378383,0.00031624,0.0008379335],"category_scores_gemma":[0.002461345,0.0002099129,0.0005174776,0.0005876626,0.0002340262,0.0003971495,0.0004466463,0.0004759101,0.0001279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000499431,"about_ca_system_score_gemma":0.0005082543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004419278,"about_ca_topic_score_gemma":0.008752331,"domain_scores_codex":[0.9994549,0.0002384549,0.00004578015,0.0001161644,0.00006333876,0.00008137777],"domain_scores_gemma":[0.9978808,0.0002924304,0.001264635,0.0002360971,0.00009561937,0.000230394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001433738,0.00003506964,0.9968551,0.00000699485,0.00005327716,0.00002801924,0.0000279084,0.00009337466,0.0001018105,0.000009466116,0.0002141223,0.001141016],"study_design_scores_gemma":[0.0001013042,0.000408923,0.9984749,0.000003827073,0.0000615922,0.0001070374,0.00005101821,0.0004865873,0.00007899111,0.00001384896,0.0002076951,0.000004243446],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990465,0.00009387678,0.00004181654,0.00002514414,0.00000272734,0.00000945984,0.0006581587,0.00000339146,0.0001189519],"genre_scores_gemma":[0.9985898,0.00002424158,0.00006068454,0.0000173762,0.00000576609,0.00001365878,0.001206403,0.000001763563,0.000080382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004419278,"threshold_uncertainty_score":0.008807898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07017764310688307,"score_gpt":0.432330976317524,"score_spread":0.3621533332106409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}