{"id":"W4410812750","doi":"10.1093/toxsci/kfaf078","title":"A mixture of organophosphate esters sex-specifically impacts monocyte–macrophages in Sprague-Dawley rats","year":2025,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Health Canada; McGill University","keywords":"Offspring; Monocyte; Immune system; Chemokine; Endocrinology; Internal medicine; Biology; Macrophage; Organophosphate; Cytokine; Basal (medicine); Immunology; Chemistry; In vitro; Medicine; Biochemistry; Pregnancy; Genetics; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006973108,0.0001903548,0.0003319419,0.00006390119,0.0001312257,0.00006083012,0.0006907842,0.0001177521,0.000834255],"category_scores_gemma":[0.0005608462,0.000118452,0.00007960567,0.001065246,0.001132851,0.0001673996,0.000375358,0.0002056699,0.00005473982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009989263,"about_ca_system_score_gemma":0.00002734583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001598089,"about_ca_topic_score_gemma":0.0001061889,"domain_scores_codex":[0.9981096,0.0001118232,0.0003706556,0.0005350218,0.0003443167,0.0005285853],"domain_scores_gemma":[0.9990752,0.0004518472,0.0001492508,0.0001875661,0.000008809263,0.000127317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005290694,0.0003794377,0.1947345,0.00002313808,0.000007105583,0.00007297067,0.0001456851,0.0009745694,0.7932495,0.000490739,0.001745974,0.00812346],"study_design_scores_gemma":[0.0005088184,0.0004063493,0.3702988,0.00008357916,0.0000105583,0.000005258709,0.00023241,0.0004435354,0.6233447,0.002704813,0.001679206,0.0002819647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833235,0.0003090853,0.000018338,0.001113312,0.0001182949,0.0002579811,0.000003370207,0.00004228211,0.01481381],"genre_scores_gemma":[0.9974745,0.0001087748,0.001280525,0.000630541,0.00001457761,0.00001218847,7.688733e-7,0.000004073432,0.0004740374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1755643,"threshold_uncertainty_score":0.9134507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01338642729803855,"score_gpt":0.3430972588204352,"score_spread":0.3297108315223967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}