{"id":"W4410815601","doi":"10.1200/jco.2025.43.16_suppl.e12629","title":"Comparative effectiveness and safety of neoadjuvant chemotherapy in combination with pembrolizumab for triple negative breast cancer: A real-world analysis from Alberta, Canada.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Occupational Cancer Research Centre","funders":"","keywords":"Medicine; Pembrolizumab; Triple-negative breast cancer; Breast cancer; Oncology; Chemotherapy; Internal medicine; Cancer; Triple negative; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0020848,0.0005728416,0.0007410895,0.0009658608,0.0009801278,0.001212543,0.001388082,0.0006912051,0.00175095],"category_scores_gemma":[0.004195738,0.0003399717,0.001236943,0.003347207,0.0009382667,0.0002789826,0.0006857374,0.0006912434,0.0002191019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02764932,"about_ca_system_score_gemma":0.02345137,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.936996,"about_ca_topic_score_gemma":0.9524999,"domain_scores_codex":[0.9979988,0.0004554455,0.0001303745,0.000253833,0.0007334136,0.0004281004],"domain_scores_gemma":[0.9947413,0.0008520477,0.001704022,0.0002427308,0.001396416,0.001063381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01997796,0.0006637117,0.9493014,0.0005987935,0.002359996,0.0003755338,0.0003873091,0.001643119,0.0007185934,0.0002544785,0.004659762,0.01905924],"study_design_scores_gemma":[0.001678933,0.001405951,0.9910782,0.0001198601,0.001213,0.0001979561,0.0005396121,0.001063795,0.000127061,0.00004902385,0.002483114,0.00004352162],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855587,0.004524143,0.0001502716,0.0003903837,0.00002829538,0.0002329066,0.007236775,0.00001421975,0.001864211],"genre_scores_gemma":[0.9925994,0.001371524,0.0002504234,0.0003634027,0.00003218275,0.00006599234,0.004692457,0.000007663071,0.0006169734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06300396,"threshold_uncertainty_score":0.2006108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02090193623467238,"score_gpt":0.3887212795047319,"score_spread":0.3678193432700595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}