{"id":"W4410815858","doi":"10.1200/jco.2025.43.16_suppl.tps8115","title":"KEYMAKER-U01E: A phase 2 umbrella study with rolling arms of investigational agents with or without chemotherapy plus pembrolizumab for resectable stage II–IIIB (N2) non–small-cell lung cancer (NSCLC).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Pembrolizumab; Chemotherapy; Lung cancer; Stage (stratigraphy); Phases of clinical research; Oncology; non-small cell lung cancer (NSCLC); Cancer; Internal medicine; Surgery; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005071753,0.002297477,0.00190844,0.0006955665,0.0006452278,0.001609728,0.002054256,0.002760206,0.01010446],"category_scores_gemma":[0.001807301,0.001353832,0.001616244,0.0005219899,0.001521522,0.00211062,0.0006939335,0.005239085,0.002839711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001355094,"about_ca_system_score_gemma":0.002126174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007179647,"about_ca_topic_score_gemma":0.002165853,"domain_scores_codex":[0.9987347,0.0007186871,0.00003820718,0.0001860372,0.0001065189,0.0002157964],"domain_scores_gemma":[0.9990557,0.0001515449,0.0001714123,0.0001240987,0.00004614181,0.0004511708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6911022,0.1624566,0.00428989,0.0009012514,0.001295573,0.0002360276,0.0003252185,0.002033451,0.05134093,0.0008319865,0.008979832,0.07620692],"study_design_scores_gemma":[0.6859496,0.3006794,0.004088685,0.00003371848,0.0003709983,0.0002356093,0.00006213245,0.00107187,0.003105177,0.0003023386,0.004064986,0.00003550063],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715455,0.00293212,0.001961989,0.001651483,0.0005849536,0.01228787,0.003362469,0.0003810416,0.005292573],"genre_scores_gemma":[0.9384375,0.002667561,0.01094275,0.00424678,0.0005385583,0.02166099,0.005817978,0.000194715,0.01549315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01010446,"threshold_uncertainty_score":0.03380275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1084795806204427,"score_gpt":0.5293499109900792,"score_spread":0.4208703303696366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}