{"id":"W4410817224","doi":"10.1200/jco.2025.43.16_suppl.4178","title":"Concurrent mutations in DNA damage repair genes <i>BRCA1</i> , <i>POLE</i> , <i>ATM</i> and <i>FANCA</i> to predict overall and progression-free survival for patients (pts) with metastatic pancreatic ductal adenocarcinoma (mPDAC) treated with chemotherapy in combination with dual checkpoint inhibition in the CCTG randomized PA.7 trial.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bausch Health (Canada); Moncton Hospital; Centre Hospitalier de l’Université de Montréal; St. Michael's Hospital; Jewish General Hospital; Centre hospitalier universitaire de Québec; University Health Network; Ottawa Hospital; University of Calgary; Princess Margaret Cancer Centre; Vancouver General Hospital; University of Toronto; Pancreas Centre (Canada); London Health Sciences Centre; Queen's University; Centre Hospitalier Universitaire de Sherbrooke; University of British Columbia","funders":"","keywords":"FANCA; Medicine; Cancer research; DNA damage; Gene; Mutation; DNA Damage Repair; DNA repair; DNA; Genetics; Fanconi anemia; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002067297,0.0007329807,0.0009241861,0.0002985405,0.0001734351,0.000571978,0.0005511866,0.0007077871,0.001368267],"category_scores_gemma":[0.00176494,0.0003173889,0.0009584333,0.0002926624,0.0003626187,0.0004054323,0.0003056422,0.001185054,0.000252676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007010187,"about_ca_system_score_gemma":0.0008216539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186213,"about_ca_topic_score_gemma":0.00346715,"domain_scores_codex":[0.9994268,0.0003665947,0.00002789275,0.00009370263,0.00004150458,0.00004355583],"domain_scores_gemma":[0.9988186,0.0004334319,0.0003259392,0.00009059684,0.0000609366,0.000270561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8216124,0.005092801,0.1125433,0.0005207394,0.003042289,0.00006876254,0.0001021743,0.002387348,0.006317717,0.00009931805,0.001616029,0.04659702],"study_design_scores_gemma":[0.319574,0.2732102,0.3723019,0.0002647775,0.01032274,0.0006697578,0.0001226249,0.01388341,0.005024386,0.0006952517,0.003845459,0.00008550665],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975056,0.001211264,0.0001692115,0.0001478661,0.00002710189,0.0002382205,0.0002950439,0.00001390507,0.0003918023],"genre_scores_gemma":[0.9974299,0.00035114,0.0005409148,0.0001537314,0.00006016742,0.0002516978,0.0008231704,0.000005341833,0.000383992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002067297,"threshold_uncertainty_score":0.01093304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04657022406597526,"score_gpt":0.4043914414846345,"score_spread":0.3578212174186592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}