{"id":"W4410818946","doi":"10.1200/jco.2025.43.16_suppl.tps4631","title":"LEGEND: A phase 1/2 study of detalimogene voraplasmid (EG-70), an intravesical monotherapy for patients with high-risk non–muscle-invasive bladder cancer (NMIBC).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Bladder cancer; Urology; Cancer; Urothelial cancer; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001211218,0.0008538617,0.001178077,0.0002951006,0.000468314,0.0007674013,0.0008135926,0.00151195,0.04380297],"category_scores_gemma":[0.001007787,0.0004787667,0.0008544127,0.0003266824,0.0003338766,0.0008657694,0.0002463961,0.00336355,0.006719727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006704087,"about_ca_system_score_gemma":0.001800571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009745836,"about_ca_topic_score_gemma":0.005460864,"domain_scores_codex":[0.9996791,0.0001221426,0.00002747018,0.00006836998,0.00004918572,0.00005364722],"domain_scores_gemma":[0.9993201,0.00009100334,0.00008284266,0.00003938692,0.0000829089,0.0003837378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4060587,0.03252322,0.004299939,0.004632539,0.00123338,0.0005960735,0.0002050483,0.002576498,0.06710894,0.002171341,0.3165687,0.1620256],"study_design_scores_gemma":[0.5613362,0.2317035,0.02065418,0.0005222991,0.001091975,0.001281351,0.0001322388,0.001794478,0.007837364,0.001355086,0.1721947,0.00009664144],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5477819,0.02405404,0.0101847,0.02530714,0.007638962,0.1078847,0.185029,0.002376936,0.08974263],"genre_scores_gemma":[0.6875648,0.01341378,0.02585649,0.02963841,0.001836532,0.06691182,0.08561245,0.0004834765,0.0886822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04380297,"threshold_uncertainty_score":0.1465356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05554571607439263,"score_gpt":0.4534230053431536,"score_spread":0.3978772892687609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}