{"id":"W4410819075","doi":"10.1016/j.chom.2025.05.003","title":"Targeted inhibition of pathobiont virulence factor mitigates alcohol-associated liver disease","year":2025,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"San Diego Digestive Diseases Research Center, School of Medicine, University of California, San Diego; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Wellcome Trust; National Institute on Alcohol Abuse and Alcoholism; Deutsche Forschungsgemeinschaft; Biomedical Laboratory Research and Development, VA Office of Research and Development; U.S. Department of Veterans Affairs","keywords":"Virulence; Biology; Virulence factor; Escherichia coli; Microbiology; Liver disease; Alcoholic liver disease; Alcoholic hepatitis; Gene; Genetics; Cirrhosis; Internal medicine; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001450641,0.0001829994,0.0003265408,0.0001730187,0.0001041556,0.00001240554,0.00006438152,0.0001416277,0.000456156],"category_scores_gemma":[0.0001790487,0.0001724339,0.0001435768,0.0002798145,0.0001201472,0.00006707858,0.0000553756,0.0002176407,0.0001739677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001571631,"about_ca_system_score_gemma":0.0002979331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000846746,"about_ca_topic_score_gemma":0.00001464143,"domain_scores_codex":[0.998787,0.00009626633,0.0003633863,0.0003069504,0.000151517,0.000294886],"domain_scores_gemma":[0.9989906,0.0001086492,0.0001654813,0.0002642753,0.0002327388,0.0002382536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002208366,0.0004605552,0.04154497,0.001033103,0.00003158717,0.00005637806,0.0002654411,5.206206e-7,0.9508627,0.00005432475,0.004886197,0.0005834042],"study_design_scores_gemma":[0.002314837,0.0001100227,0.5741156,0.001025883,0.0001496406,0.000001625928,0.00003805761,0.0001039928,0.4187058,0.00002344623,0.003248633,0.0001623826],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927816,0.004611896,0.0001035344,0.0006501541,0.0002309154,0.0007483529,0.0001820711,0.00009823003,0.000593192],"genre_scores_gemma":[0.994336,0.0006667527,0.0001404021,0.002383617,0.00002776252,0.00002396797,0.0002258414,0.00001801029,0.002177614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5325707,"threshold_uncertainty_score":0.7031649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03029757454682546,"score_gpt":0.3095366543186011,"score_spread":0.2792390797717756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}