{"id":"W4410819075","doi":"10.1016/j.chom.2025.05.003","title":"Targeted inhibition of pathobiont virulence factor mitigates alcohol-associated liver disease","year":2025,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"San Diego Digestive Diseases Research Center, School of Medicine, University of California, San Diego; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Wellcome Trust; National Institute on Alcohol Abuse and Alcoholism; Deutsche Forschungsgemeinschaft; Biomedical Laboratory Research and Development, VA Office of Research and Development; U.S. Department of Veterans Affairs","keywords":"Virulence; Biology; Virulence factor; Escherichia coli; Microbiology; Liver disease; Alcoholic liver disease; Alcoholic hepatitis; Gene; Genetics; Cirrhosis; Internal medicine; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001094045,0.0003914209,0.0004378974,0.0001677169,0.0001489707,0.0002932403,0.0001791948,0.0002665145,0.002432236],"category_scores_gemma":[0.0001217763,0.0001291248,0.0002768602,0.0001009178,0.0003010007,0.0002251412,0.0002064447,0.001085588,0.0002869892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002563934,"about_ca_system_score_gemma":0.0004303324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001270912,"about_ca_topic_score_gemma":0.00324495,"domain_scores_codex":[0.9999098,0.00001388006,0.00000524495,0.00001192742,0.0000142408,0.00004496903],"domain_scores_gemma":[0.9999398,0.000004411317,0.00001395876,0.000004464679,0.00000820165,0.00002910842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01042484,0.001752266,0.001121103,0.0003514071,0.0001314522,0.0001120918,0.00004726056,0.0005092746,0.9613648,0.0004490181,0.0009384733,0.02279793],"study_design_scores_gemma":[0.001157571,0.02727492,0.03029775,0.0001180549,0.0004576302,0.0003489894,0.0003843411,0.004482123,0.9200002,0.0006678092,0.01475845,0.00005212172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929797,0.002976275,0.001516194,0.0003817222,0.0001884527,0.00005396456,0.0003314806,0.000151639,0.00142057],"genre_scores_gemma":[0.9946674,0.001728716,0.0006823517,0.0001449311,0.00002462019,0.00003290394,0.0002790023,0.00001040641,0.002429564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002432236,"threshold_uncertainty_score":0.00813663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03029757454682546,"score_gpt":0.3095366543186011,"score_spread":0.2792390797717756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}