{"id":"W4410820396","doi":"10.1200/jco.2025.43.16_suppl.tps2100","title":"Update on GBM AGILE: A global, phase 2/3 adaptive platform trial to evaluate multiple regimens in newly diagnosed and recurrent glioblastoma.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Glioblastoma; Oncology; Internal medicine; Medical physics; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007904819,0.001047027,0.00202302,0.0009511327,0.0004209183,0.002067191,0.001556252,0.00222792,0.008713254],"category_scores_gemma":[0.01126349,0.0004241271,0.002549,0.001106324,0.0004964875,0.001755174,0.001072089,0.004402183,0.002779697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001221861,"about_ca_system_score_gemma":0.002717972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001503036,"about_ca_topic_score_gemma":0.006158225,"domain_scores_codex":[0.99799,0.001031798,0.0001660822,0.0001386411,0.0004971671,0.0001762388],"domain_scores_gemma":[0.9936348,0.002428027,0.001087309,0.0002914175,0.001130206,0.001428182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.03640296,0.001134164,0.002409428,0.004711922,0.002114309,0.0002731636,0.0001758217,0.00217909,0.004691907,0.003016539,0.3832981,0.5595926],"study_design_scores_gemma":[0.1632354,0.03061594,0.01816984,0.00621009,0.004189868,0.0009568845,0.0001498067,0.002828034,0.002979957,0.010578,0.7598777,0.0002084859],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1379063,0.2271526,0.03766241,0.2066406,0.0280261,0.02668527,0.141936,0.007272027,0.1867186],"genre_scores_gemma":[0.2648374,0.1678271,0.07343856,0.2495551,0.01543425,0.05003272,0.1099559,0.002581236,0.06633785],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008713254,"threshold_uncertainty_score":0.04180515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1290640087615006,"score_gpt":0.4986660372666736,"score_spread":0.3696020285051731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}