{"id":"W4410821212","doi":"10.1200/jco.2025.43.16_suppl.7028","title":"Postmarketing safety profile of chimeric antigen receptor (CAR) T cell therapies in diffuse large B-cell lymphoma (DLBCL): Analysis of real-world (RW) AE reporting from the FDA Adverse Event Reporting System (FAERS).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"EVERSANA (Canada)","funders":"","keywords":"Chimeric antigen receptor; Medicine; Safety profile; Adverse effect; Lymphoma; Adverse Event Reporting System; Postmarketing surveillance; Diffuse large B-cell lymphoma; Pharmacovigilance; Oncology; Antigen; Internal medicine; Cancer research; Immunology; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01201116,0.0003496805,0.0004887655,0.001911691,0.0001877666,0.0008643027,0.0003472324,0.0004364509,0.001888852],"category_scores_gemma":[0.01954665,0.0001766484,0.002052347,0.001751249,0.0004197261,0.0007445811,0.0004930146,0.0007363931,0.0003185354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007829973,"about_ca_system_score_gemma":0.000662579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009087819,"about_ca_topic_score_gemma":0.001088298,"domain_scores_codex":[0.9893643,0.003848242,0.001822688,0.00146332,0.003085587,0.0004159394],"domain_scores_gemma":[0.9528936,0.01362338,0.02757634,0.002051284,0.00324934,0.0006060532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007049986,0.0003824534,0.9555312,0.0004813515,0.002413813,0.0002236636,0.000152116,0.001486391,0.002423944,0.0002024239,0.001274406,0.02837831],"study_design_scores_gemma":[0.0002044583,0.002357158,0.9879233,0.00006887534,0.0007955559,0.0008137668,0.00009149491,0.002922392,0.002035139,0.0001303333,0.002631332,0.00002616064],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873765,0.003312876,0.001357471,0.0001570778,0.00001940171,0.0002487394,0.006131413,0.00004688554,0.001349661],"genre_scores_gemma":[0.9939874,0.0003527365,0.0005215895,0.0001135513,0.00002863849,0.0001127443,0.004642306,0.00001503908,0.0002258259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01201116,"threshold_uncertainty_score":0.0635218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06189013748469961,"score_gpt":0.4346572815657052,"score_spread":0.3727671440810055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}