{"id":"W4410821527","doi":"10.1200/jco.2025.43.16_suppl.tps3164","title":"TUB-030, a novel ADC targeting 5T4: A phase I/IIa multi-center, first-in-human clinical trial (5-STAR 1-01) in patients with advanced solid tumors.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Solid tumor; Center (category theory); Oncology; Cancer research; Internal medicine; Nuclear medicine; Cancer; Crystallography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00421809,0.0002554241,0.001559108,0.0002115865,0.00008176517,0.00001988617,0.0005322769,0.0005975622,0.00003533741],"category_scores_gemma":[0.006412874,0.0001969241,0.0005216355,0.0002214167,0.0003205827,0.00002386815,0.0002748398,0.001384198,0.000004027875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009626485,"about_ca_system_score_gemma":0.001324414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002599785,"about_ca_topic_score_gemma":0.0003855856,"domain_scores_codex":[0.9938031,0.0007281606,0.004020899,0.0005363216,0.0003517719,0.0005597007],"domain_scores_gemma":[0.9967583,0.0007926699,0.001428133,0.0003248563,0.0003701146,0.0003259235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3852055,0.09182715,0.448256,0.0001016656,0.0007411304,0.0007472361,0.00006786961,0.0003752239,0.00614479,0.00003383332,0.003523072,0.06297653],"study_design_scores_gemma":[0.7281917,0.06646532,0.1176267,0.0005155493,0.0001044993,0.000007894005,0.0001546983,0.0008877264,0.001127249,0.0000356463,0.0844069,0.0004761756],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967163,0.0002248499,0.0007051845,0.0007317386,0.0008264419,0.0005818731,0.0000231334,0.000004599157,0.000185863],"genre_scores_gemma":[0.9943433,0.0003724296,0.003572086,0.0007238434,0.0007697939,0.00001900048,0.00005160698,0.00002663134,0.0001213506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3429862,"threshold_uncertainty_score":0.8030332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08850909577830092,"score_gpt":0.5084399677602239,"score_spread":0.419930871981923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}