{"id":"W4410821527","doi":"10.1200/jco.2025.43.16_suppl.tps3164","title":"TUB-030, a novel ADC targeting 5T4: A phase I/IIa multi-center, first-in-human clinical trial (5-STAR 1-01) in patients with advanced solid tumors.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Solid tumor; Center (category theory); Oncology; Cancer research; Internal medicine; Nuclear medicine; Cancer; Crystallography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001798648,0.001414331,0.0008428182,0.0003635015,0.0004981865,0.001013645,0.000796281,0.001549361,0.002776578],"category_scores_gemma":[0.0005381409,0.000474805,0.0008511774,0.0003946368,0.0007023424,0.000893063,0.0004030468,0.002531328,0.0008717976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001263571,"about_ca_system_score_gemma":0.001715102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001084469,"about_ca_topic_score_gemma":0.002366985,"domain_scores_codex":[0.9996867,0.0001205992,0.00001861926,0.00005795561,0.00003355122,0.00008253555],"domain_scores_gemma":[0.9995434,0.00003659517,0.000105399,0.00003467429,0.00003657033,0.0002433308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4149442,0.1210549,0.01586566,0.001688066,0.001633402,0.0008763084,0.0008905857,0.008248192,0.1851484,0.001346693,0.02047251,0.227831],"study_design_scores_gemma":[0.3466016,0.5839423,0.01573686,0.00009084235,0.0006339406,0.001653074,0.000168186,0.00375471,0.03266885,0.0005024292,0.01418669,0.0000605685],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859395,0.002790763,0.001330396,0.0007769693,0.0001162797,0.003698461,0.002240631,0.0002437181,0.002863302],"genre_scores_gemma":[0.9840934,0.001824406,0.002748522,0.001177688,0.00008163439,0.002462507,0.004052417,0.00004890108,0.003510513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002776578,"threshold_uncertainty_score":0.009512246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08850909577830092,"score_gpt":0.5084399677602239,"score_spread":0.419930871981923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}