{"id":"W4410822229","doi":"10.1200/jco.2025.43.16_suppl.3114","title":"Development and validation of a biology-based novel therapeutic agent targeting the LIN28/ <i>let-7</i> pathway in cancer.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Medicine; Cancer; Cancer research; Computational biology; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004262656,0.0006634842,0.0005586333,0.0003583844,0.0002501002,0.0005003924,0.0006097746,0.000705209,0.001205981],"category_scores_gemma":[0.0002398794,0.0002244786,0.0007217962,0.0001804145,0.0002856032,0.0003160856,0.0002433219,0.0008588912,0.0008579277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005784734,"about_ca_system_score_gemma":0.000778053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005978876,"about_ca_topic_score_gemma":0.001018327,"domain_scores_codex":[0.9998466,0.00003521163,0.000007985847,0.00002957694,0.00005798013,0.00002265463],"domain_scores_gemma":[0.9998876,0.00001325292,0.00002730195,0.00001151295,0.00003013844,0.00003017995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002400256,0.0004617548,0.0004507508,0.0004419465,0.00006601818,0.0001771336,0.00002747196,0.005249288,0.9703761,0.0005319187,0.0005046831,0.02147289],"study_design_scores_gemma":[0.0002750095,0.004375452,0.0007920135,0.00004725548,0.0001985022,0.000737601,0.00002500384,0.008361347,0.9611965,0.0002105589,0.0237525,0.00002824597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8589826,0.03137565,0.08875526,0.001289208,0.0004595562,0.00261014,0.002915125,0.0009209355,0.01269157],"genre_scores_gemma":[0.8968641,0.01647666,0.07493024,0.0005140023,0.0000613158,0.0007935509,0.004023297,0.0001051191,0.006231585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001205981,"threshold_uncertainty_score":0.00419718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08940132134343319,"score_gpt":0.3986550221679462,"score_spread":0.309253700824513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}