{"id":"W4410822512","doi":"10.1200/jco.2025.43.16_suppl.tps3171","title":"A first-in-human multi-center phase 1/2 study of a selective FGFR2/3 inhibitor, CGT4859, in patients with intrahepatic cholangiocarcinomas or other advanced solid tumors.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Unum Therapeutics","keywords":"Medicine; Solid tumor; Intrahepatic Cholangiocarcinoma; Oncology; Internal medicine; Cancer research; Radiology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001173613,0.0001789299,0.001085636,0.0002954782,0.00002880754,0.000007543858,0.0003139357,0.0002540677,0.00001598457],"category_scores_gemma":[0.001723452,0.0001237704,0.0001447493,0.0003212563,0.0001531742,0.00001663232,0.0001776662,0.0007180875,0.000001005845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001237289,"about_ca_system_score_gemma":0.0007357272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005668082,"about_ca_topic_score_gemma":0.00248907,"domain_scores_codex":[0.9964472,0.0005973876,0.002062362,0.0003166777,0.0002664622,0.0003099172],"domain_scores_gemma":[0.9979545,0.0002929719,0.0009566661,0.0002331931,0.0004366713,0.0001259431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01871469,0.02860654,0.9457374,0.00004766729,0.0002499013,0.00009262384,0.0002539638,0.00009733099,0.002625738,0.000002048585,0.0001364409,0.003435658],"study_design_scores_gemma":[0.07862692,0.06283224,0.8545447,0.0002548062,0.0000377396,0.000004978224,0.0002432304,0.00007631284,0.002707218,0.00001517272,0.0005178665,0.0001388185],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988587,0.00004476034,0.00007552552,0.0000900231,0.0001492607,0.0006521035,0.000007113451,0.000002045796,0.0001204476],"genre_scores_gemma":[0.9991332,0.00001146004,0.0005111521,0.000143814,0.00008886011,0.00001987467,0.000004370108,0.0000206399,0.0000666155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09119269,"threshold_uncertainty_score":0.5047209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04407917643325134,"score_gpt":0.4446313771914444,"score_spread":0.4005522007581931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}