{"id":"W4410827616","doi":"10.1101/2025.05.27.656174","title":"Cholinergic synaptic plasticity shapes resilience and vulnerability to tau","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba; Université du Québec à Montréal; York University; Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital; Robarts Clinical Trials; Lawson Health Research Institute; Western University","funders":"","keywords":"Vulnerability (computing); Resilience (materials science); Neuroscience; Cholinergic; Synaptic plasticity; Plasticity; Metaplasticity; Psychology; Biology; Computer science; Physics; Computer security","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001088058,0.0002055653,0.0002469739,0.0003143768,0.0001526415,0.0004698278,0.0001557046,0.0003606985,0.0008041165],"category_scores_gemma":[0.0002998269,0.0001490266,0.0001762976,0.0001103729,0.0002626965,0.0002907779,0.0003497222,0.0003602295,0.0002308813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002223551,"about_ca_system_score_gemma":0.0001504064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000920243,"about_ca_topic_score_gemma":0.001363735,"domain_scores_codex":[0.9999427,0.000004752653,0.000004559663,0.00001714388,0.00001374507,0.00001715248],"domain_scores_gemma":[0.9999017,0.000008250508,0.00002936625,0.00001356607,0.00001593049,0.00003119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003250919,0.00004281111,0.01662519,0.00004701442,0.00005479616,0.0003774148,0.0001358803,0.0002842122,0.9711089,0.0004010239,0.0001888612,0.01040882],"study_design_scores_gemma":[0.00003013985,0.0005419612,0.7884156,0.00004570336,0.0001204483,0.001857497,0.0004700459,0.003430116,0.2008544,0.00266415,0.001544156,0.00002581418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980112,0.0005200498,0.0004341327,0.00005591755,0.0000067285,0.00000383108,0.0000729676,0.00002719694,0.0008678932],"genre_scores_gemma":[0.9990355,0.0002861941,0.0001423818,0.00002057709,0.00000377251,0.00000364211,0.00004713958,0.000004718102,0.0004560839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000920243,"threshold_uncertainty_score":0.002690077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03408221023565872,"score_gpt":0.3043950632576343,"score_spread":0.2703128530219756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}