{"id":"W4410835789","doi":"10.1016/j.jbiotec.2025.05.013","title":"Substitution of reactive centre loop residues from C1 esterase inhibitor increases the inhibitory specificity of alpha-1 antitrypsin for plasma kallikrein","year":2025,"lang":"en","type":"article","venue":"Journal of Biotechnology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; Canadian Blood Services; McMaster University","funders":"Canadian Blood Services","keywords":"Inhibitory postsynaptic potential; Alpha (finance); Chemistry; Kallikrein; Biochemistry; Biology; Endocrinology; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003078304,0.000157488,0.000591729,0.0004121779,0.00007271664,0.000008494097,0.0001817282,0.0003681811,0.0000232644],"category_scores_gemma":[0.0006891434,0.0001128884,0.0002372027,0.0003320996,0.0004736153,0.0001168468,0.00005579538,0.000303769,9.358627e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009134239,"about_ca_system_score_gemma":0.0003091686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003254963,"about_ca_topic_score_gemma":0.000188584,"domain_scores_codex":[0.9985277,0.00006320629,0.0008344044,0.0001777825,0.000219982,0.0001769446],"domain_scores_gemma":[0.9980109,0.000465334,0.0008464842,0.0002869606,0.0003410074,0.00004926456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004818855,0.001091437,0.06223025,0.0002447554,0.0006950056,0.00006721084,0.0004322846,0.00002518462,0.8951144,0.009783668,0.008280628,0.01721627],"study_design_scores_gemma":[0.002393575,0.0004285668,0.04365457,0.0008356951,0.0003038603,0.00004558837,0.0007999046,0.0001400357,0.9468193,0.001515142,0.002979264,0.00008450131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911249,0.00325561,0.000743521,0.003973799,0.0004300813,0.0003113561,0.00007236837,0.00002436917,0.00006395869],"genre_scores_gemma":[0.9976199,0.0004553225,0.001405146,0.00008090759,0.0002779611,0.000001815672,0.00001743892,0.00001101678,0.0001304745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05170485,"threshold_uncertainty_score":0.4603455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01309649595937266,"score_gpt":0.2630391113685345,"score_spread":0.2499426154091618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}