{"id":"W4410836386","doi":"10.1111/jcmm.70589","title":"miR‐486‐5p Inhibits eNOS and Angiogenesis in Cultured Endothelial Cells by Targeting MAML3","year":2025,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Ottawa Hospital Foundation; Kidney Foundation of Canada; Ottawa Hospital Research Institute; Canadian Institutes of Health Research; University of Ottawa","keywords":"Enos; Angiogenesis; Transfection; Biology; Endothelial stem cell; Umbilical vein; Messenger RNA; Small interfering RNA; Downregulation and upregulation; Molecular biology; Cell biology; Nitric oxide; Nitric oxide synthase; Cell culture; Cancer research; Endocrinology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000207563,0.000308812,0.0003666035,0.0001650368,0.0001579282,0.0002355159,0.0001843683,0.0002414288,0.001522952],"category_scores_gemma":[0.0001821084,0.0001533786,0.0003415603,0.0001123608,0.0002292836,0.0001561404,0.0001789839,0.0005719243,0.0004857328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002402955,"about_ca_system_score_gemma":0.0002737029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003665349,"about_ca_topic_score_gemma":0.0005830589,"domain_scores_codex":[0.9998318,0.00002843043,0.00002220097,0.00003257477,0.00004687913,0.00003811646],"domain_scores_gemma":[0.9999384,0.00001147588,0.00001921403,0.000008119843,0.00000886003,0.00001403982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003721041,0.00006409767,0.0001736392,0.00006988286,0.0000096577,0.00002835071,0.00002199018,0.00007249301,0.9967678,0.0000712412,0.0001415291,0.002207324],"study_design_scores_gemma":[0.00004233971,0.0004263042,0.00164455,0.000005835988,0.00002170867,0.000103326,0.00001867178,0.000865431,0.9936052,0.00003735262,0.00322586,0.000003459503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908936,0.001984099,0.003579848,0.0002988278,0.0001140232,0.00004638478,0.0006476425,0.0003175671,0.002117973],"genre_scores_gemma":[0.9914429,0.001078677,0.003902441,0.0001375807,0.00002245224,0.00009436264,0.0008032635,0.00004603576,0.002472327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001522952,"threshold_uncertainty_score":0.005094826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002884573302857804,"score_gpt":0.2192881617331025,"score_spread":0.2164035884302447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}