{"id":"W4410844913","doi":"10.20944/preprints202505.2093.v1","title":"Preliminary Evaluation of Formulations for Stability of mRNA-LNPs Through Freeze-Thaw Stresses and Long-Term Storage","year":2025,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Term (time); Stability (learning theory); Structural engineering; Engineering; Computer science; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005827735,0.0002633884,0.0003685068,0.00006313289,0.00009311003,0.000009343899,0.0002887815,0.0003807821,0.0001766588],"category_scores_gemma":[0.0006308557,0.0002699784,0.0002673432,0.00006338503,0.0001527541,0.00001197308,0.001233522,0.0001611518,0.000001005398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003316662,"about_ca_system_score_gemma":0.000407245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001774905,"about_ca_topic_score_gemma":0.00009851831,"domain_scores_codex":[0.998018,0.0001959502,0.0005723881,0.0007399097,0.0002901261,0.0001836115],"domain_scores_gemma":[0.9974233,0.0000735784,0.0005064252,0.001114454,0.0008199796,0.00006225918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000446848,0.0004891165,0.8202053,0.002101766,0.0003140698,2.431736e-7,0.0003115083,0.004284916,0.1707203,0.0001089032,0.0001625653,0.0008545414],"study_design_scores_gemma":[0.0006359086,0.0001637744,0.4837263,0.0002677188,0.0003013033,7.745388e-7,0.00004209133,0.0002631472,0.5115237,0.002813615,0.00007375775,0.0001879244],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912825,0.001992932,0.002493548,0.00003153534,0.0003547561,0.001657009,0.001094155,0.00001688125,0.001076713],"genre_scores_gemma":[0.9978758,0.0004085584,0.0003048226,0.0000195346,0.0001033789,0.000459046,0.0006946907,0.00001879761,0.0001153656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3408034,"threshold_uncertainty_score":0.9999753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1240205378069803,"score_gpt":0.3985243052942034,"score_spread":0.274503767487223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}