{"id":"W4410845263","doi":"10.1016/j.ebiom.2025.105753","title":"Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder","year":2025,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire de Gériatrie de Montréal; Baycrest Hospital; Women and Children’s Health Research Institute; Montreal General Hospital; Université du Québec à Montréal; Hôpital du Sacré-Cœur de Montréal; Montreal Neurological Institute and Hospital","funders":"NIHR Newcastle Biomedical Research Centre; Medical Research Council; Fonds de Recherche du Québec - Santé; Italfarmaco; Canadian Institutes of Health Research; Ipsen; H. Lundbeck A/S; Servier; Idorsia Pharmaceuticals; Agentura Pro Zdravotnický Výzkum České Republiky; Électricité de France; Newcastle upon Tyne Hospitals NHS Foundation Trust; Eisai; Else Kröner-Fresenius-Stiftung; Universität zu Köln; Canada Research Chairs; Newcastle University; Seqirus; Parkinson's UK; Parkinson Vereniging; Michael J. Fox Foundation for Parkinson's Research; Parkinson Society Canada; European Commission; University of Alberta; Parkinson Canada; Agence Nationale de la Recherche; Alzheimer Society; Alzheimer's Society; TauRx Pharmaceuticals; Parkinsonforeningen; Consortium canadien en neurodégénérescence associée au vieillissement; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Novo Nordisk; Jascha Fonden; EU Joint Programme – Neurodegenerative Disease Research; National Institutes of Health; Regeneron Pharmaceuticals; NIHR Oxford Biomedical Research Centre; Biogen; National Health and Medical Research Council; International Parkinson and Movement Disorder Society; Aarhus Universitet; Lundbeckfonden; BrightFocus Foundation; Eli Lilly and Company","keywords":"Atrophy; Sleep (system call); Neuroscience; Medicine; REM sleep behavior disorder; Pathology; Psychology; Electroencephalography; Polysomnography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005001077,0.0002924463,0.000280604,0.0005511835,0.0002431461,0.0003366132,0.0002962739,0.0002648876,0.001331716],"category_scores_gemma":[0.001438163,0.0001688703,0.0003703089,0.0003624845,0.0002593065,0.0001924034,0.0003464813,0.0002542407,0.000185069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002704614,"about_ca_system_score_gemma":0.0002314555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005731681,"about_ca_topic_score_gemma":0.01206215,"domain_scores_codex":[0.9998349,0.0000325799,0.00002035212,0.00006535612,0.00002624503,0.00002052346],"domain_scores_gemma":[0.9993319,0.000126132,0.000331979,0.00007879141,0.00007640091,0.00005478696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004761549,0.000034657,0.9892117,0.00001592445,0.00006343621,0.0002937185,0.0001831321,0.0002651982,0.003747103,0.0000396503,0.00008890587,0.005580417],"study_design_scores_gemma":[0.000004816971,0.00004737574,0.9985726,0.00000475905,0.00001535042,0.0005533849,0.00005300268,0.0004599,0.0001795994,0.00006552583,0.0000420224,0.00000173285],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994005,0.00007365813,0.0002204874,0.00000751953,0.000001002064,0.000008671516,0.0001255546,0.000006265701,0.0001563275],"genre_scores_gemma":[0.9993829,0.00003103818,0.0002317075,0.000006049865,0.000001402917,0.000004216648,0.000273457,0.000003689334,0.00006548694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005731681,"threshold_uncertainty_score":0.01139665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00782021236574897,"score_gpt":0.2876409291898279,"score_spread":0.2798207168240789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}