{"id":"W4410846072","doi":"10.1021/acsomega.5c02274","title":"Molecular Imprints of Clinical Comorbidities in Hypothalamic Extracellular Vesicles at the Onset of Obesity","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Departament de Salut, Generalitat de Catalunya; Instituto de Salud Carlos III; Universitat de Lleida; Ministerio de Ciencia, Innovación y Universidades; Brock University; European Social Fund; Seventh Framework Programme; Centres de Recerca de Catalunya; Universitat Rovira i Virgili; NextGenerationEU; Agència de Gestió d'Ajuts Universitaris i de Recerca; Generalitat de Catalunya","keywords":"Leptin; Obesity; Bioinformatics; Extracellular; Adiponectin; Pathological; Neuroinflammation; Extracellular vesicles; Internal medicine; Medicine; Biology; Endocrinology; Neuroscience; Insulin resistance; Inflammation; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000733771,0.0001508885,0.000297575,0.00006040603,0.00003959647,0.000006740776,0.0004905394,0.0001857719,0.000009213464],"category_scores_gemma":[0.0004478653,0.0001307124,0.000196663,0.0001640321,0.0005070689,0.000004039916,0.0004390465,0.0001503969,0.000005677808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001710174,"about_ca_system_score_gemma":0.0001472796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004540568,"about_ca_topic_score_gemma":0.00006280776,"domain_scores_codex":[0.9983602,0.000276396,0.0006619825,0.0003241863,0.0001689469,0.0002083492],"domain_scores_gemma":[0.9986797,0.0001233184,0.0002190919,0.0008521942,0.00007911505,0.00004656957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001343579,0.0003163284,0.1565427,0.0000812303,0.00008160321,0.00002337549,0.00002989678,0.00008463491,0.8399945,0.000663559,0.0006529985,0.001394819],"study_design_scores_gemma":[0.0006408143,0.00006673834,0.1223051,0.00004093482,0.00003764709,0.000003984709,0.00008519619,0.00003808603,0.8742716,0.0008742566,0.00152643,0.0001091636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914825,0.007044381,0.0001580694,0.0001301581,0.0001342901,0.000228537,0.00004827616,0.000005972681,0.0007678032],"genre_scores_gemma":[0.9984446,0.0003284914,0.0001682744,0.000113713,0.0000250266,0.00001336401,0.00004947302,0.00001557373,0.0008415052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0342771,"threshold_uncertainty_score":0.5330295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0168302634492363,"score_gpt":0.306857355036751,"score_spread":0.2900270915875147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}