{"id":"W4410846072","doi":"10.1021/acsomega.5c02274","title":"Molecular Imprints of Clinical Comorbidities in Hypothalamic Extracellular Vesicles at the Onset of Obesity","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Departament de Salut, Generalitat de Catalunya; Instituto de Salud Carlos III; Universitat de Lleida; Ministerio de Ciencia, Innovación y Universidades; Brock University; European Social Fund; Seventh Framework Programme; Centres de Recerca de Catalunya; Universitat Rovira i Virgili; NextGenerationEU; Agència de Gestió d'Ajuts Universitaris i de Recerca; Generalitat de Catalunya","keywords":"Leptin; Obesity; Bioinformatics; Extracellular; Adiponectin; Pathological; Neuroinflammation; Extracellular vesicles; Internal medicine; Medicine; Biology; Endocrinology; Neuroscience; Insulin resistance; Inflammation; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001962382,0.0002363041,0.0003413326,0.0004890737,0.0002046751,0.0005983861,0.0001602114,0.0004348848,0.001672682],"category_scores_gemma":[0.0006155546,0.0001794034,0.000241291,0.0003160287,0.0002834436,0.0003060373,0.0004506129,0.0006570845,0.0001667213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002368752,"about_ca_system_score_gemma":0.0001803171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004780024,"about_ca_topic_score_gemma":0.0003816625,"domain_scores_codex":[0.9998714,0.00002454827,0.000009534047,0.00004561132,0.00002090937,0.00002809812],"domain_scores_gemma":[0.999594,0.00006094007,0.0001833642,0.00003336369,0.00003184035,0.00009645784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01267819,0.0002968047,0.7330113,0.0001875455,0.0003165296,0.006885484,0.0002948966,0.0004091123,0.2108868,0.001341717,0.0006170322,0.03307457],"study_design_scores_gemma":[0.00002305218,0.0004029964,0.9871622,0.00002922434,0.00006488937,0.002976924,0.000163628,0.0004218926,0.007339573,0.0005806728,0.000818079,0.000016886],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966112,0.001504745,0.0005752656,0.00009328533,0.00002398623,0.00001065488,0.0003230184,0.00001966985,0.0008381584],"genre_scores_gemma":[0.9984773,0.000462125,0.0002796042,0.00003223368,0.00001731032,0.000009163917,0.0002858058,0.000009124848,0.0004274822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672682,"threshold_uncertainty_score":0.005595684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0168302634492363,"score_gpt":0.306857355036751,"score_spread":0.2900270915875147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}