{"id":"W4410859581","doi":"10.1016/j.ccell.2025.05.002","title":"Microbial cancer immunotherapy reprograms hematopoiesis to enhance myeloid-driven anti-tumor immunity","year":2025,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Science Foundation; Canadian Institutes of Health Research; Royal Society of Canada; Fonds de Recherche du Québec - Santé; Ludwig Institute for Cancer Research; Memorial Sloan-Kettering Cancer Center; Burroughs Wellcome Fund; National Heart, Lung, and Blood Institute; U.S. Department of Defense; National Cancer Institute; National Institutes of Health","keywords":"Haematopoiesis; Immunotherapy; Myeloid cells; Immunity; Cancer; Myeloid; Cancer research; Biology; Cancer immunotherapy; Immunology; Immune system; Stem cell; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002083639,0.0002824862,0.0001990292,0.0002575458,0.0001248802,0.000441519,0.0001296426,0.000320164,0.002331855],"category_scores_gemma":[0.0001650892,0.00008606842,0.0001457871,0.0001030814,0.0002092409,0.0002049275,0.0002833707,0.001180146,0.0005321745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002156054,"about_ca_system_score_gemma":0.0001760602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008778515,"about_ca_topic_score_gemma":0.0002271581,"domain_scores_codex":[0.9998085,0.00005149459,0.000008823491,0.00002755066,0.00004790321,0.00005571913],"domain_scores_gemma":[0.9999278,0.0000132232,0.00001924423,0.00001152899,0.000008005087,0.00002033538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003295212,0.0001939029,0.0006366898,0.0000909957,0.000009979669,0.00009519666,0.00003509113,0.0003993153,0.9750803,0.00204188,0.0005339721,0.0205531],"study_design_scores_gemma":[0.0001267017,0.001923651,0.01098557,0.00005427911,0.00004208051,0.0006146809,0.0001440724,0.003773991,0.9563878,0.001175339,0.02476223,0.000009699529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744703,0.006725126,0.006994649,0.0009774056,0.0003290515,0.0001094755,0.0003071503,0.0003392723,0.009747467],"genre_scores_gemma":[0.9948065,0.001106918,0.001605882,0.0001679236,0.00007359724,0.0000246315,0.0001020964,0.00001864749,0.002093817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002331855,"threshold_uncertainty_score":0.007800817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008585827248009293,"score_gpt":0.3000140486265898,"score_spread":0.2914282213785805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}