{"id":"W4410861796","doi":"10.3390/cells14110785","title":"Transcriptomic Analyses of Ovarian Clear Cell Carcinoma Spheroids Reveal Distinct Proliferative Phenotypes and Therapeutic Vulnerabilities","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; London Health Sciences Centre","funders":"London Health Sciences Foundation","keywords":"Spheroid; Biology; Cancer research; Anoikis; Cell biology; Cell growth; Cellular pathology; Cell culture; Cell; Transcriptome; Cancer cell; Cancer; Pathology; Gene expression; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000189081,0.0002112378,0.0004789197,0.0004852823,0.0003358585,0.0005260853,0.0001083943,0.000252578,0.001153542],"category_scores_gemma":[0.0002764442,0.0001538696,0.0003963061,0.0007413749,0.0001641795,0.000248299,0.0002449579,0.0005029433,0.000407264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002992755,"about_ca_system_score_gemma":0.0003537929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004046,"about_ca_topic_score_gemma":0.00188038,"domain_scores_codex":[0.9998112,0.0000102453,0.00001125369,0.00007208838,0.00005820766,0.00003714094],"domain_scores_gemma":[0.9998652,0.00003691631,0.00003111366,0.00001078389,0.000041285,0.00001478933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000206979,0.00001676854,0.006484489,0.0002327582,0.00004070997,0.0001365692,0.0001599065,0.0005214199,0.9847291,0.0001858651,0.0006268183,0.006658585],"study_design_scores_gemma":[0.00003944334,0.0004838567,0.4874135,0.0001154736,0.0003170609,0.0009133185,0.001210516,0.0127288,0.459416,0.0009691906,0.03630166,0.00009122857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9338824,0.004297324,0.008375639,0.0002251479,0.00007403224,0.000100617,0.04944955,0.0003210755,0.003274204],"genre_scores_gemma":[0.9336365,0.003333901,0.01055426,0.0003344579,0.00003046543,0.0003696835,0.04704849,0.000185821,0.004506335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153542,"threshold_uncertainty_score":0.003858924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598230461623747,"score_gpt":0.2765625867251851,"score_spread":0.2605802821089476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}