{"id":"W4410864461","doi":"10.3390/vaccines13060581","title":"Optimized Production of Virus-like Particles in a High-CHO-Cell-Density Transient Gene Expression System for Foot-and-Mouth Disease Vaccine Development","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"Animal Disease Management and Epidemiology","field":"Agricultural and Biological Sciences","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación","keywords":"Virology; Foot-and-mouth disease virus; Gene; Virus; Gene expression; Transient (computer programming); Biology; Cell; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002918929,0.0001284183,0.0002730269,0.00003335008,0.0001138386,0.00001121647,0.00009539477,0.00004330692,0.00001038544],"category_scores_gemma":[0.00007042815,0.00005431225,0.00005708574,0.0001971019,0.000009222574,0.00006300789,0.00006352385,0.00003102871,0.000001350051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002448042,"about_ca_system_score_gemma":0.000009621509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001145794,"about_ca_topic_score_gemma":0.000177784,"domain_scores_codex":[0.9989688,0.00008152569,0.0003485565,0.0003368187,0.00006746186,0.0001968377],"domain_scores_gemma":[0.9996217,0.00009841322,0.00009371777,0.00005680673,0.00005693406,0.00007240402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008460356,0.0007381449,0.1282449,0.0009441642,0.00006807061,0.000005984381,0.0002685331,0.0009614371,0.8283106,0.0005922359,0.003466217,0.02793929],"study_design_scores_gemma":[0.001093265,0.00005907372,0.9319168,0.0001312925,0.00006511724,1.895405e-7,0.000352711,0.0005585564,0.06455317,0.000151805,0.0009746493,0.0001433164],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970523,0.0004070175,0.0002671357,0.001270215,0.0001752993,0.0007591617,0.00001125873,0.00004647154,0.00001111406],"genre_scores_gemma":[0.9983005,0.00007250297,0.001128626,0.00006373013,0.00005988573,0.0001650303,0.00005065871,0.000001028519,0.0001580544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8036719,"threshold_uncertainty_score":0.2214789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01854235028736031,"score_gpt":0.2278926147399884,"score_spread":0.2093502644526281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}