{"id":"W4410864461","doi":"10.3390/vaccines13060581","title":"Optimized Production of Virus-like Particles in a High-CHO-Cell-Density Transient Gene Expression System for Foot-and-Mouth Disease Vaccine Development","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"Animal Disease Management and Epidemiology","field":"Agricultural and Biological Sciences","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación","keywords":"Virology; Foot-and-mouth disease virus; Gene; Virus; Gene expression; Transient (computer programming); Biology; Cell; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005574047,0.0004636664,0.0004092404,0.0002879606,0.0002163855,0.000534253,0.0004173201,0.0004851981,0.0006962018],"category_scores_gemma":[0.000311775,0.000162793,0.000482653,0.0004316825,0.0002018454,0.0003714927,0.000242945,0.0006733875,0.0007736576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006074003,"about_ca_system_score_gemma":0.0003834649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007565741,"about_ca_topic_score_gemma":0.0008611078,"domain_scores_codex":[0.9996686,0.00005910606,0.00005248726,0.00006819435,0.0001056015,0.00004613574],"domain_scores_gemma":[0.999899,0.00002254621,0.00002564563,0.00001548825,0.00002790327,0.000009363321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003317424,0.00002624509,0.0001026796,0.00004575431,0.000004719336,0.00003439455,0.00001481787,0.00022475,0.9986145,0.00008438804,0.00002883562,0.0007856254],"study_design_scores_gemma":[0.00001408268,0.0001598306,0.0008016133,0.000005213794,0.00002011143,0.0001028258,0.00001508522,0.001444035,0.9953551,0.00003809555,0.002036588,0.00000744196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8974366,0.001300922,0.09489803,0.0002159799,0.0001132267,0.0005052615,0.002062856,0.000367978,0.003099283],"genre_scores_gemma":[0.8821598,0.001539744,0.1061785,0.00007085621,0.00002159719,0.0005257721,0.005704169,0.0001318612,0.003667846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007565741,"threshold_uncertainty_score":0.004407048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01854235028736031,"score_gpt":0.2278926147399884,"score_spread":0.2093502644526281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}