{"id":"W4410868023","doi":"10.1016/j.cdnut.2025.107313","title":"Variations in Phenotype, Methylation Potential and Gene Expression of Methyltransferases in Wistar Rat Offspring Exposed to Choline or Betaine Prenatally","year":2025,"lang":"en","type":"article","venue":"Current Developments in Nutrition","topic":"Birth, Development, and Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Offspring; Methyltransferase; Betaine; Phenotype; Methylation; Choline; Biology; Gene; Epigenetics; DNA methylation; Genetics; Gene expression; Pregnancy; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000531762,0.0001781741,0.0004086736,0.00120622,0.00004460177,0.00001306698,0.00007550565,0.0001116805,0.00001667337],"category_scores_gemma":[0.0001773697,0.0001720008,0.00002364082,0.001030349,0.00002462783,0.0001716677,0.00005294757,0.0002383553,0.000001193466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000309403,"about_ca_system_score_gemma":0.0004271238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003672571,"about_ca_topic_score_gemma":0.0002591551,"domain_scores_codex":[0.9981424,0.0001090399,0.0008502312,0.0003754097,0.0002563106,0.0002665903],"domain_scores_gemma":[0.9995053,0.00006565317,0.00008810016,0.0001332474,0.000119888,0.000087841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004180533,0.004238621,0.18542,0.006766943,0.00005415549,0.00004625493,0.005161798,0.0001489754,0.7020093,0.003696951,0.0001983336,0.08807821],"study_design_scores_gemma":[0.01393319,0.0001401178,0.635615,0.007515204,0.00003546023,0.000003933711,0.0002358543,0.0003362253,0.3376502,0.003684256,0.0005282225,0.0003223942],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804468,0.001323196,0.0156762,0.0004108427,0.0003825666,0.001593595,0.00001894166,0.00002434025,0.0001235419],"genre_scores_gemma":[0.9486564,0.01334142,0.03735195,0.00009873307,0.00003300217,0.000190343,0.0003018359,0.00001260975,0.00001366135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.450195,"threshold_uncertainty_score":0.7013989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03201893985727839,"score_gpt":0.3289792915189574,"score_spread":0.2969603516616791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}