{"id":"W4410876084","doi":"10.1093/braincomms/fcaf210","title":"Brain MRI signatures across sex and CSF Alzheimer’s disease biomarkers","year":2025,"lang":"en","type":"article","venue":"Brain Communications","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; European Federation of Pharmaceutical Industries and Associations; Pfizer; Novartis Pharmaceuticals Corporation; Eli Lilly and Company; McMaster University; BioClinica; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; Biogen; Northern California Institute for Research and Education; Massachusetts General Hospital; Foundation for the National Institutes of Health","keywords":"Neuroscience; Disease; Medicine; Psychology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","sts"],"consensus_categories":[],"category_scores_codex":[0.0005226645,0.0001985362,0.0001846427,0.000133546,0.001562333,0.000156609,0.0009943492,0.00007220667,0.00001759582],"category_scores_gemma":[0.01676193,0.0002039381,0.00008514879,0.0006707489,0.001022601,0.00023825,0.001504125,0.0002991364,0.00002554002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004557598,"about_ca_system_score_gemma":0.0001154432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005443637,"about_ca_topic_score_gemma":0.0002023266,"domain_scores_codex":[0.9981548,0.0005719371,0.0002353881,0.0005253222,0.0002005659,0.000311994],"domain_scores_gemma":[0.9730021,0.02492249,0.00007899335,0.001806379,0.00006795015,0.000122082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001473463,0.000526731,0.006179019,0.00005514764,0.0002952056,0.00001124136,0.001798534,0.0001240472,0.03515917,0.1579976,0.769982,0.02772395],"study_design_scores_gemma":[0.0009886681,0.00004498759,0.06287354,0.00009409354,0.00007898799,0.000006690967,0.0008515213,0.005605583,0.003941659,0.02205325,0.9029552,0.0005058282],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.02362338,0.009024874,0.0007875303,0.9429926,0.0003561733,0.0009227901,0.0003489031,0.000453974,0.02148973],"genre_scores_gemma":[0.9452973,0.0003831542,0.0006920545,0.05016545,0.00002973525,0.0002023928,0.0000215597,0.00002160495,0.003186747],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.9216739,"threshold_uncertainty_score":0.9997375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05749337384719918,"score_gpt":0.3533085007402626,"score_spread":0.2958151268930634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}