{"id":"W4410876964","doi":"10.1080/19420862.2025.2512217","title":"Does one model fit all mAbs? An evaluation of population pharmacokinetic models","year":2025,"lang":"en","type":"article","venue":"mAbs","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Pharmacokinetics; Population; Population pharmacokinetics; Computer science; Computational biology; Medicine; Biology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0402027,0.002701622,0.005631005,0.002153462,0.000435717,0.003487121,0.003516091,0.003019301,0.003433723],"category_scores_gemma":[0.07439709,0.001193863,0.01170801,0.002004511,0.0006528763,0.003151925,0.001035405,0.003760232,0.000759684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002390191,"about_ca_system_score_gemma":0.002422195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01019007,"about_ca_topic_score_gemma":0.005230179,"domain_scores_codex":[0.9802133,0.01580334,0.0007523192,0.002122119,0.00077939,0.0003294625],"domain_scores_gemma":[0.9212799,0.07337189,0.002012769,0.001488143,0.001500478,0.0003468984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.003517695,0.000295115,0.04546082,0.00672802,0.0591116,0.001138506,0.0004897091,0.7596143,0.001117308,0.01171365,0.01190394,0.09890933],"study_design_scores_gemma":[0.001104779,0.002288914,0.01336545,0.001884651,0.03164076,0.001241568,0.0004332228,0.8593129,0.001109453,0.06048919,0.02687071,0.0002583802],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2679327,0.1472917,0.5353202,0.01829683,0.0009894001,0.001759411,0.01741539,0.001781564,0.009212809],"genre_scores_gemma":[0.8748547,0.02056544,0.08662956,0.005221181,0.0005886643,0.001285589,0.008254375,0.0006690212,0.001931479],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0402027,"threshold_uncertainty_score":0.2126148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8192363584553051,"score_gpt":0.6473883407274934,"score_spread":0.1718480177278117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}