{"id":"W4410876964","doi":"10.1080/19420862.2025.2512217","title":"Does one model fit all mAbs? An evaluation of population pharmacokinetic models","year":2025,"lang":"en","type":"article","venue":"mAbs","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Pharmacokinetics; Population; Population pharmacokinetics; Computer science; Computational biology; Medicine; Biology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.004388459,0.0001336789,0.0004124508,0.0001017098,0.00003563363,0.00001880581,0.0001914675,0.0001271294,0.0003426924],"category_scores_gemma":[0.01219923,0.00009451556,0.00008254436,0.0001599336,0.00004359445,0.0001243591,0.00006727426,0.0001332728,0.000005385359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008179908,"about_ca_system_score_gemma":0.00004382766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003335691,"about_ca_topic_score_gemma":0.00001169461,"domain_scores_codex":[0.9972606,0.0007866297,0.0008296518,0.0002999547,0.0006578586,0.0001653151],"domain_scores_gemma":[0.9945362,0.004395595,0.0002349773,0.0004635429,0.0003087767,0.00006096168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002676055,0.0008802761,0.000120987,0.0005028339,0.0001859208,5.906866e-7,0.0002286927,0.1095349,0.00308319,0.7743369,0.0008964619,0.1099617],"study_design_scores_gemma":[0.0006193895,0.00001886173,0.0002367971,0.00005244974,0.0003004886,5.023651e-8,0.000005830458,0.4804416,0.0007619905,0.5174993,0.000005129597,0.00005817431],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.206393,0.00003502378,0.7874925,0.0009794916,0.0006279871,0.001091556,0.00008792792,0.000102871,0.003189688],"genre_scores_gemma":[0.5913237,0.00001059033,0.408165,0.0001333645,0.0000567075,0.00004835497,0.000009124999,0.00001355769,0.000239562],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.3849308,"threshold_uncertainty_score":0.9961214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8192363584553051,"score_gpt":0.6473883407274934,"score_spread":0.1718480177278117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}