{"id":"W4410878021","doi":"10.1016/j.bbi.2025.05.027","title":"HDAC inhibitors engage MITF and the disease-associated microglia signature to enhance amyloid β uptake","year":2025,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"Thompson Foundation; Chan Zuckerberg Initiative; National Institute on Aging; National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; National Institute of Mental Health; Henry and Marilyn Taub Foundation","keywords":"Microglia; Microphthalmia-associated transcription factor; Amyloid (mycology); Signature (topology); Amyloid β; Neuroscience; Disease; Medicine; Chemistry; Biology; Immunology; Biochemistry; Internal medicine; Pathology; Gene; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007568444,0.0001938492,0.0001936266,0.00007216197,0.0005219187,0.00007508139,0.0002444453,0.0001918265,0.00001522093],"category_scores_gemma":[0.0009802178,0.0001602939,0.00009029476,0.0002153574,0.0003831681,0.000006319825,0.0003855364,0.000490758,0.000004744566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003319342,"about_ca_system_score_gemma":0.000106377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001302191,"about_ca_topic_score_gemma":0.0001198399,"domain_scores_codex":[0.9984998,0.000473563,0.0002196083,0.0003545485,0.0001495956,0.0003029287],"domain_scores_gemma":[0.9990926,0.0001086876,0.00004696288,0.0004781021,0.0001126331,0.0001610279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004326697,0.0001596087,0.002056901,0.00002133581,0.00003387416,0.000008370786,0.0003124253,5.808559e-7,0.9716629,0.00003321177,0.01822866,0.007049394],"study_design_scores_gemma":[0.002363496,0.0002844156,0.2194086,0.0001260018,0.0001116378,0.000007589855,0.0005807226,0.000008236739,0.7129722,0.00005956125,0.06358499,0.0004924585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932077,0.003838959,0.00002169585,0.001691682,0.0001438419,0.0006280331,0.0001037827,0.00001690358,0.0003474203],"genre_scores_gemma":[0.9936558,0.000183045,0.0000399689,0.0008594214,0.00005476718,0.0001286791,0.0001018774,0.00001796944,0.0049585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2586907,"threshold_uncertainty_score":0.6536594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006413292637609857,"score_gpt":0.287624405220604,"score_spread":0.2812111125829941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}