{"id":"W4410885072","doi":"10.1016/j.immuni.2025.05.004","title":"Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction","year":2025,"lang":"en","type":"article","venue":"Immunity","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Office of Extramural Research, National Institutes of Health; National Institutes of Health; Ragon Institute of MGH, MIT and Harvard; Massachusetts Institute of Technology; Dana-Farber Cancer Institute; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Biology; Antibody; Mycobacterium tuberculosis; Tuberculosis; Virology; Microbiology; Mycobacterium; Immunology; Bacteria; Genetics; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000200276,0.0002135766,0.0001458545,0.0001492848,0.00007832197,0.0002175218,0.0001664197,0.000285086,0.0009262247],"category_scores_gemma":[0.0002186032,0.0001121668,0.0001673713,0.0001016806,0.0001372122,0.0001325557,0.0002582769,0.0003262193,0.000309809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916729,"about_ca_system_score_gemma":0.0001046725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003694422,"about_ca_topic_score_gemma":0.0003752674,"domain_scores_codex":[0.9998179,0.00003306019,0.000008649347,0.00002618653,0.00003986082,0.00007434693],"domain_scores_gemma":[0.9999132,0.0000206378,0.00002281302,0.0000100709,0.00001456487,0.00001877778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003408525,0.000009433123,0.0002365656,0.000009843269,0.000001588632,0.00002454064,0.000006790648,0.00005963316,0.9989145,0.00006359278,0.00001334515,0.0006261338],"study_design_scores_gemma":[0.00001591191,0.0003410889,0.007738881,0.000006833599,0.00001669942,0.0003070334,0.00002794802,0.001118475,0.9877566,0.00009358046,0.002573853,0.000003136943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935638,0.00069339,0.004101307,0.00005923116,0.00001009152,0.00002812124,0.00008296517,0.00004844048,0.001412598],"genre_scores_gemma":[0.9970263,0.0001585945,0.001937825,0.00007690106,0.000004968935,0.0000134198,0.0000946575,0.000008673584,0.0006786181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009262247,"threshold_uncertainty_score":0.003098547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597613300203124,"score_gpt":0.3451343192735586,"score_spread":0.3291581862715274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}