{"id":"W4410885072","doi":"10.1016/j.immuni.2025.05.004","title":"Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction","year":2025,"lang":"en","type":"article","venue":"Immunity","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Office of Extramural Research, National Institutes of Health; National Institutes of Health; Ragon Institute of MGH, MIT and Harvard; Massachusetts Institute of Technology; Dana-Farber Cancer Institute; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Biology; Antibody; Mycobacterium tuberculosis; Tuberculosis; Virology; Microbiology; Mycobacterium; Immunology; Bacteria; Genetics; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005246966,0.0001402181,0.000324988,0.0002189892,0.000209739,0.00002786045,0.00009110022,0.0001823331,0.00005559363],"category_scores_gemma":[0.00116623,0.0001134158,0.00007700384,0.0003632352,0.0001423981,0.00009375536,0.0001469888,0.0006095097,0.00003855537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007392243,"about_ca_system_score_gemma":0.00009137719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001811711,"about_ca_topic_score_gemma":0.00006994692,"domain_scores_codex":[0.9987954,0.0002900968,0.0002199164,0.0002292205,0.0001251415,0.0003401948],"domain_scores_gemma":[0.9990797,0.0001901303,0.00003714865,0.0004398186,0.0001177519,0.0001354572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001394154,0.0005048847,0.4363071,0.0006616146,0.0005912632,0.000058105,0.0002834941,0.000001748827,0.4935417,0.001172035,0.03041593,0.035068],"study_design_scores_gemma":[0.0006873054,0.0003114157,0.9743791,0.0001314905,0.0000763037,0.00006146159,0.00006127786,0.00006421484,0.003595849,0.0004908095,0.0200508,0.0000899285],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716448,0.001973845,0.00008325616,0.01012272,0.0002004459,0.0003337833,0.00001839949,0.00009231373,0.01553039],"genre_scores_gemma":[0.9935139,0.003361828,0.0003651004,0.001081619,0.00008860194,0.00002065582,0.0002718206,0.00001090065,0.001285519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.538072,"threshold_uncertainty_score":0.4624961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597613300203124,"score_gpt":0.3451343192735586,"score_spread":0.3291581862715274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}