{"id":"W4410886534","doi":"10.1126/sciimmunol.ads7377","title":"Human LY9 governs CD4 <sup>+</sup> T cell IFN-γ immunity to <i>Mycobacterium tuberculosis</i>","year":2025,"lang":"en","type":"article","venue":"Science Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; BC Children's Hospital","funders":"National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; National Center for Advancing Translational Sciences; Howard Hughes Medical Institute","keywords":"T cell; RAR-related orphan receptor gamma; Biology; CXCR3; Immunology; C-C chemokine receptor type 6; Population; Memory T cell; CD28; Interleukin 21; T-cell receptor; Immune system; FOXP3; Medicine; Chemokine receptor; Chemokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000807089,0.0003662914,0.0004503817,0.0007457468,0.001528487,0.0001130336,0.001270652,0.0003926151,0.002524101],"category_scores_gemma":[0.0002676993,0.0003553552,0.0001797343,0.001417967,0.001310522,0.0005407235,0.0007730125,0.0009204019,0.004891604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004493567,"about_ca_system_score_gemma":0.0003473853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001101715,"about_ca_topic_score_gemma":0.00003636054,"domain_scores_codex":[0.9971051,0.0003369487,0.0006138066,0.0007997694,0.0001000394,0.00104434],"domain_scores_gemma":[0.998173,0.0001176742,0.0001664932,0.001141475,0.0003499505,0.00005143084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001446435,0.0002552111,0.000718349,0.00001400527,0.00008024894,0.000001839574,0.0006774242,0.00004076364,0.9728221,0.002015593,0.02129694,0.001932829],"study_design_scores_gemma":[0.001133675,0.0005066444,0.02096278,0.0000541378,0.00004978217,0.0000598262,0.002134509,0.00001700985,0.6184877,0.0001518306,0.3560487,0.0003934249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9223314,0.001091729,0.0002599234,0.001534016,0.007901774,0.0004309854,0.00001114241,0.0002499675,0.06618908],"genre_scores_gemma":[0.9330122,0.00006670941,0.00006048484,0.002277417,0.00003371149,0.00006251554,0.00006315325,0.00001932627,0.0644045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3543345,"threshold_uncertainty_score":0.9998899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007463855271852832,"score_gpt":0.248154005208943,"score_spread":0.2406901499370902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}