{"id":"W4410894568","doi":"10.3390/molecules30112399","title":"Gating Mechanism for Biased Agonism at Angiotensin II Type 1 Receptors","year":2025,"lang":"en","type":"article","venue":"Molecules","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Victoria University; RMIT University","keywords":"Chemistry; Carboxylate; Angiotensin II; Receptor; Biophysics; Stereochemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001679465,0.000169914,0.0002089189,0.000112586,0.0002580232,0.0003876812,0.0005389436,0.0003488155,0.002582376],"category_scores_gemma":[0.0002240136,0.0001226111,0.0002196294,0.00005599989,0.0003453205,0.0004129118,0.0003341811,0.0004452624,0.0003710114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002608847,"about_ca_system_score_gemma":0.0001860623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001418588,"about_ca_topic_score_gemma":0.0001673898,"domain_scores_codex":[0.9998847,0.0000174253,0.000005419865,0.00002287208,0.0000303325,0.00003937026],"domain_scores_gemma":[0.9999434,0.00002003097,0.000009881365,0.000006326824,0.000006620787,0.00001373298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003369783,0.0000646328,0.0004542343,0.0001215565,0.00001993765,0.0006395838,0.0001366814,0.001597131,0.9460275,0.03700383,0.000782596,0.01281534],"study_design_scores_gemma":[0.0004409447,0.002015583,0.009011053,0.00007066063,0.0001030032,0.003382938,0.0003731522,0.2028422,0.7041188,0.05590327,0.02158544,0.0001529571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9016115,0.001719461,0.0707347,0.001492633,0.0002974238,0.0001329985,0.000209188,0.0006831135,0.02311909],"genre_scores_gemma":[0.9963239,0.0004149077,0.001843178,0.0001832789,0.0000355522,0.00002549048,0.00002291883,0.00001487828,0.001135892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002582376,"threshold_uncertainty_score":0.008638918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124507147843684,"score_gpt":0.2545384756880195,"score_spread":0.2420877609036511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}