{"id":"W4410903318","doi":"10.4014/jmb.2504.04007","title":"Acidic pH Reduces Fluconazole Susceptibility in <i>Cryptococcus neoformans</i> by Altering Iron Uptake and Enhancing Ergosterol Biosynthesis","year":2025,"lang":"en","type":"article","venue":"Journal of Microbiology and Biotechnology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Korea National Institute of Health; National Institutes of Health; National Research Foundation of Korea; Chung-Ang University; Ministry of Science, ICT and Future Planning; National Research Foundation; Canadian Institute for Advanced Research","keywords":"Cryptococcus neoformans; Fluconazole; Ergosterol; Cryptococcosis; Microbiology; Antifungal drug; Fungus; Biology; Intracellular; Cryptococcus; Biochemistry; Antifungal; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003778888,0.0001351313,0.0004601796,0.000349932,0.0001014667,0.000007467663,0.00006387858,0.0003947696,0.00001266909],"category_scores_gemma":[0.0001101836,0.0001004898,0.00005105101,0.00016642,0.000503047,0.00005331162,0.000100527,0.0004583215,0.000001120242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005007347,"about_ca_system_score_gemma":0.00003965213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002133909,"about_ca_topic_score_gemma":0.0001582328,"domain_scores_codex":[0.9990687,0.00004276951,0.0004590836,0.0001864256,0.00001886447,0.0002241161],"domain_scores_gemma":[0.9995932,0.0000844305,0.0001441501,0.0001009141,0.00004605063,0.000031236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001926698,0.00007789741,0.01184661,0.00007321627,0.00007447372,0.00001418735,0.00006869785,2.551625e-7,0.9744542,0.00005011941,0.0005119511,0.01263571],"study_design_scores_gemma":[0.001111698,0.0007087927,0.008123717,0.0002257245,0.00007027178,0.0008026822,0.0008123176,0.000004070431,0.9799903,0.00007817767,0.007983301,0.00008893067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857675,0.006980225,0.00007604616,0.006725246,0.0002004064,0.0001372797,0.000008362405,0.00001772994,0.00008715497],"genre_scores_gemma":[0.9947183,0.004531616,0.0003223754,0.0003375929,0.00002484752,0.000003049774,0.000001831274,0.000004203407,0.0000561445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01254677,"threshold_uncertainty_score":0.4097853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005769089440520577,"score_gpt":0.2392509625479562,"score_spread":0.2334818731074356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}