{"id":"W4410903318","doi":"10.4014/jmb.2504.04007","title":"Acidic pH Reduces Fluconazole Susceptibility in <i>Cryptococcus neoformans</i> by Altering Iron Uptake and Enhancing Ergosterol Biosynthesis","year":2025,"lang":"en","type":"article","venue":"Journal of Microbiology and Biotechnology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Korea National Institute of Health; National Institutes of Health; National Research Foundation of Korea; Chung-Ang University; Ministry of Science, ICT and Future Planning; National Research Foundation; Canadian Institute for Advanced Research","keywords":"Cryptococcus neoformans; Fluconazole; Ergosterol; Cryptococcosis; Microbiology; Antifungal drug; Fungus; Biology; Intracellular; Cryptococcus; Biochemistry; Antifungal; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082894,0.0002815832,0.0002525869,0.0001826085,0.0001781449,0.0003367585,0.0001656264,0.0002563398,0.0009608072],"category_scores_gemma":[0.0001680577,0.00009386084,0.0002111017,0.00013798,0.0001706108,0.0001808882,0.0001985405,0.0002909925,0.0001585168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004069917,"about_ca_system_score_gemma":0.0002624229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005437877,"about_ca_topic_score_gemma":0.006310336,"domain_scores_codex":[0.999856,0.00001909054,0.00001022784,0.00002717676,0.00003994104,0.00004758756],"domain_scores_gemma":[0.9999388,0.00000852605,0.00002070794,0.000004445271,0.00001273773,0.00001468512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000215007,0.00003958415,0.001140516,0.00004743675,0.000005168296,0.00005922647,0.00001472225,0.00006967378,0.9962985,0.00002195888,0.00008245343,0.002005823],"study_design_scores_gemma":[0.00002437918,0.0006018454,0.09824239,0.00003341024,0.00003620783,0.0004878071,0.0002555605,0.002002233,0.8950901,0.0001291632,0.003077183,0.00001987476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974722,0.0005533954,0.0004385772,0.0001076416,0.00001388984,0.00001624719,0.0004822885,0.00003777786,0.0008778533],"genre_scores_gemma":[0.9976735,0.0002470688,0.0007563564,0.0001051568,0.00000413347,0.00001067144,0.000449761,0.000009406222,0.0007440602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005437877,"threshold_uncertainty_score":0.01081246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005769089440520577,"score_gpt":0.2392509625479562,"score_spread":0.2334818731074356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}