{"id":"W4410904775","doi":"10.5267/j.ccl.2025.3.003","title":"Mechanistic insights and antifungal assessment of (3+2) cycloaddition products of 2-diazopropane and 5-hydroxy-3-methyl-1,5-dihydropyrrol-2-one derivatives","year":2025,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Commission","keywords":"Chemistry; Cycloaddition; Antifungal; Stereochemistry; Combinatorial chemistry; Organic chemistry; Medicinal chemistry; Catalysis; Microbiology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001160513,0.0003299201,0.0005129899,0.0001029053,0.00009675875,0.00003003319,0.0001822442,0.00013171,0.0001473086],"category_scores_gemma":[0.000162194,0.0003484977,0.00006649834,0.0002733393,0.0003031986,0.0001346851,0.0001772732,0.0003773081,8.47123e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001107489,"about_ca_system_score_gemma":0.0001141267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000100506,"about_ca_topic_score_gemma":3.669983e-7,"domain_scores_codex":[0.9981245,0.00003222027,0.0005635223,0.000645934,0.0003736935,0.0002601625],"domain_scores_gemma":[0.9987237,0.000112257,0.0004288621,0.0004638065,0.0001763761,0.00009497067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003090133,0.0002087966,0.0004034645,0.006522493,0.00009852715,0.000003341517,0.0001718921,0.000007109974,0.9884223,0.0002980379,0.00005044127,0.003782684],"study_design_scores_gemma":[0.0008362565,0.00000874747,0.0008593381,0.0007797874,0.0001587598,0.00001189009,0.0002263663,0.0003250985,0.9957539,0.0003629244,0.0003958931,0.000281078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957486,0.001198874,0.001394286,0.0002172534,0.0001615475,0.0001921995,0.00007351882,0.00006779718,0.0009459186],"genre_scores_gemma":[0.9978395,0.0004290331,0.001320032,0.00001412107,0.0001035099,0.00004445986,0.00018699,0.00002583456,0.0000365097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00733155,"threshold_uncertainty_score":0.9998967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01065335590962149,"score_gpt":0.2622800479825683,"score_spread":0.2516266920729469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}