{"id":"W4410915295","doi":"10.1016/j.eclinm.2025.103088","title":"Predictors of withdrawal of anticancer drug indications granted accelerated approval: a retrospective cohort study","year":2025,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"Economic and Financial Impacts of Cancer","field":"Economics, Econometrics and Finance","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Regional Municipality of Durham; Queen's University","funders":"Kaiser Permanente; Brigham and Women's Hospital; Arnold Ventures; Fundación Alfonso Martín Escudero; Commonwealth Fund","keywords":"Medicine; Retrospective cohort study; Drug; Drug approval; Cohort; Family medicine; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002481846,0.0002669496,0.0004364492,0.0007738873,0.0004316811,0.0007989891,0.0004434773,0.0004214986,0.001512374],"category_scores_gemma":[0.005409255,0.0003961316,0.0008032125,0.00122201,0.0002865124,0.0006866584,0.0005464932,0.0009368691,0.0002275455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003426679,"about_ca_system_score_gemma":0.0006062404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003856675,"about_ca_topic_score_gemma":0.0035462,"domain_scores_codex":[0.9985354,0.0003289726,0.0002345007,0.0004306557,0.0002656904,0.0002047705],"domain_scores_gemma":[0.994486,0.0009505188,0.002935662,0.0007025251,0.0004058016,0.0005194761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001478608,0.00001732451,0.9990602,0.000005629059,0.00004958821,0.00005215404,0.00002621924,0.00003017477,0.00006550971,0.00001731225,0.00007985219,0.0004482791],"study_design_scores_gemma":[0.00001917085,0.0001921143,0.9980774,0.00001190899,0.0001031928,0.0005144935,0.0001680228,0.0003778903,0.00007328446,0.00003241574,0.0004216751,0.000008546304],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985021,0.0003251155,0.0001881635,0.00003944497,0.00000958108,0.00001958272,0.000646821,0.000003206626,0.0002660565],"genre_scores_gemma":[0.9991556,0.0001018267,0.00009238298,0.00002637916,0.000008577898,0.00001524012,0.0005212076,0.000003076216,0.00007566624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003856675,"threshold_uncertainty_score":0.01312542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02401752034553083,"score_gpt":0.2995410155782727,"score_spread":0.2755234952327419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}