{"id":"W4410916455","doi":"10.1007/s12311-025-01858-3","title":"Selection of Clinical Outcome Assessments for Trial Readiness in ARSACS – 2-year Progression and Responsiveness to Change Part 1: Disease Severity, Swallowing, Upper Limb Function, and Participation","year":2025,"lang":"en","type":"article","venue":"The Cerebellum","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke; Centres Intégré Universitaires de Santé et de Services Sociaux; Centre for Interdisciplinary Research in Rehabilitation; Montreal Neurological Institute and Hospital; Cégep de Jonquière; Université Laval; McGill University; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean","funders":"Canadian Institutes of Health Research","keywords":"Swallowing; Neurology; Physical medicine and rehabilitation; Selection (genetic algorithm); Outcome (game theory); Disease; Clinical trial; Medicine; Upper limb; Physical therapy; Randomized controlled trial; Psychology; Internal medicine; Psychiatry; Surgery; Computer science; Economics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01657343,0.001418319,0.002627733,0.001962466,0.001572068,0.001841161,0.001000213,0.001695115,0.004417124],"category_scores_gemma":[0.01932178,0.0002768193,0.0041508,0.001157828,0.001006818,0.002029085,0.00180069,0.001484115,0.001715496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001513776,"about_ca_system_score_gemma":0.003255773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001367671,"about_ca_topic_score_gemma":0.003878019,"domain_scores_codex":[0.9919956,0.004076231,0.001218271,0.0007593702,0.0008251352,0.001125396],"domain_scores_gemma":[0.9884299,0.002952047,0.003391575,0.001022535,0.002402261,0.001801576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1769195,0.0044814,0.6958666,0.001159394,0.002730769,0.0005005138,0.001942217,0.0027893,0.005412312,0.001956155,0.008526581,0.09771536],"study_design_scores_gemma":[0.009709889,0.0324235,0.931969,0.0005717953,0.001433598,0.0003740416,0.0009986691,0.005952792,0.003153073,0.003756785,0.009430554,0.0002262611],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970768,0.001180048,0.003971519,0.0007305812,0.00021335,0.01270653,0.002897359,0.0001246045,0.007408018],"genre_scores_gemma":[0.9779431,0.0001467579,0.003069209,0.0003105884,0.00007201236,0.01470366,0.002360934,0.00004411761,0.001349512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01657343,"threshold_uncertainty_score":0.0876497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1411748792684308,"score_gpt":0.447619118981589,"score_spread":0.3064442397131582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}