{"id":"W4410916455","doi":"10.1007/s12311-025-01858-3","title":"Selection of Clinical Outcome Assessments for Trial Readiness in ARSACS – 2-year Progression and Responsiveness to Change Part 1: Disease Severity, Swallowing, Upper Limb Function, and Participation","year":2025,"lang":"en","type":"article","venue":"The Cerebellum","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke; Centres Intégré Universitaires de Santé et de Services Sociaux; Centre for Interdisciplinary Research in Rehabilitation; Montreal Neurological Institute and Hospital; Cégep de Jonquière; Université Laval; McGill University; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean","funders":"Canadian Institutes of Health Research","keywords":"Swallowing; Neurology; Physical medicine and rehabilitation; Selection (genetic algorithm); Outcome (game theory); Disease; Clinical trial; Medicine; Upper limb; Physical therapy; Randomized controlled trial; Psychology; Internal medicine; Psychiatry; Surgery; Computer science; Economics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006758035,0.0001280639,0.0002384824,0.0001166753,0.0001485272,0.00004059115,0.0001062571,0.00005076405,0.000007941702],"category_scores_gemma":[0.002062473,0.00009892222,0.00005544577,0.0003250275,0.0001011794,0.0001131811,0.0001239847,0.0000869208,0.00000140826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001790785,"about_ca_system_score_gemma":0.0000861333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005944084,"about_ca_topic_score_gemma":0.00002474639,"domain_scores_codex":[0.9980742,0.0006412098,0.0004528414,0.0004445338,0.0001928444,0.0001943472],"domain_scores_gemma":[0.9989061,0.0005551248,0.0001261297,0.0002111754,0.00009026744,0.0001111642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04882785,0.000723255,0.923374,0.0001672355,0.0000156525,0.000001425752,0.0001350326,0.00003255432,0.01420706,0.000940424,0.0003276727,0.01124781],"study_design_scores_gemma":[0.006432476,0.0006664854,0.9677727,0.00007951562,0.00009311186,2.052e-7,0.00002860021,0.001045328,0.02208334,0.0009808774,0.000700885,0.0001164833],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954835,0.00002224043,0.0002900095,0.00137276,0.0007311787,0.002028559,0.00002576754,0.00002055206,0.00002550355],"genre_scores_gemma":[0.9981,0.0000299112,0.00006336705,0.0007383031,0.0001246403,0.0005867925,0.000004839595,0.00001256719,0.0003396196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04439867,"threshold_uncertainty_score":0.4033931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1411748792684308,"score_gpt":0.447619118981589,"score_spread":0.3064442397131582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}