{"id":"W4410919567","doi":"10.1056/nejmoa2505725","title":"Vepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Grand River Hospital; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Pfizer","keywords":"Breast cancer; Estrogen receptor; Estrogen; Oncology; Cancer; Medicine; Internal medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001060916,0.0001654695,0.0003028712,0.0001655702,0.00008997366,0.0002305865,0.0001571209,0.0002122255,0.0004494714],"category_scores_gemma":[0.0008408637,0.00006820619,0.0002678521,0.0001762589,0.0001613624,0.0001328138,0.0001231819,0.0002851879,0.00008009747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003793146,"about_ca_system_score_gemma":0.0002813594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005525913,"about_ca_topic_score_gemma":0.001006098,"domain_scores_codex":[0.9997429,0.0001299897,0.00001597349,0.00003517499,0.00004879285,0.00002720216],"domain_scores_gemma":[0.9996636,0.0001347707,0.00009688377,0.00002058905,0.00002141753,0.00006274513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.07852307,0.001820103,0.3244936,0.0009737406,0.001387068,0.001163851,0.0001714612,0.006405721,0.02677656,0.0005437097,0.002877872,0.5548633],"study_design_scores_gemma":[0.01194779,0.08269597,0.8442473,0.0002395745,0.001855669,0.006643429,0.0001618129,0.01209435,0.01969091,0.001399694,0.01898558,0.00003784521],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858084,0.01289194,0.0004344923,0.0002040944,0.00001881143,0.00002688567,0.00007112099,0.00001835601,0.0005260026],"genre_scores_gemma":[0.9971973,0.00223014,0.0002810575,0.00004884498,0.00001826908,0.000009164117,0.00006852125,0.000001287355,0.000145359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001060916,"threshold_uncertainty_score":0.005610764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007023828941751299,"score_gpt":0.2787799944642537,"score_spread":0.2717561655225024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}