{"id":"W4410919567","doi":"10.1056/nejmoa2505725","title":"Vepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Grand River Hospital; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Pfizer","keywords":"Breast cancer; Estrogen receptor; Estrogen; Oncology; Cancer; Medicine; Internal medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002973705,0.0001047882,0.0002008768,0.0001171295,0.00002161594,0.00000510603,0.0001382342,0.00007145548,0.00007828182],"category_scores_gemma":[0.0001458025,0.00007407334,0.00004457507,0.0001615522,0.00005079405,0.000006947999,0.00001689403,0.0001757378,7.711576e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002530392,"about_ca_system_score_gemma":0.0002840664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006217595,"about_ca_topic_score_gemma":0.00005168596,"domain_scores_codex":[0.9991941,0.00005896742,0.0003465808,0.0001196671,0.0001437935,0.0001368495],"domain_scores_gemma":[0.999522,0.00001350239,0.0001490414,0.0001092135,0.0001047275,0.000101464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001211106,0.00006683332,0.02302881,0.00003299045,0.00007202587,0.00001551597,0.0001027845,0.00005526089,0.5881584,0.0001396272,0.02011132,0.3670053],"study_design_scores_gemma":[0.06279889,0.001355113,0.02130247,0.001534913,0.00007282881,0.0003863365,0.0002563928,0.00002328448,0.2752834,0.0004224359,0.6362891,0.0002748501],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720855,0.008346183,0.0006635331,0.01728004,0.0007572204,0.0002193676,0.000007497095,0.000004335442,0.0006362995],"genre_scores_gemma":[0.9938222,0.00195047,0.0006268448,0.000608872,0.00181696,0.000008583075,0.00001206836,0.000009551552,0.001144515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6161777,"threshold_uncertainty_score":0.3020623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007023828941751299,"score_gpt":0.2787799944642537,"score_spread":0.2717561655225024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}