{"id":"W4410922540","doi":"10.1038/s41388-025-03461-6","title":"Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinoma","year":2025,"lang":"en","type":"article","venue":"Oncogene","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute; Government of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; Cancer research; Persistence (discontinuity); Drug; Adenocarcinoma; Lung; Signal transduction; Carcinogenesis; Pharmacology; Internal medicine; Cell biology; Cancer; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001201634,0.0001804804,0.0002392464,0.000287608,0.0002038605,0.0003547683,0.0001047293,0.0002329912,0.001118123],"category_scores_gemma":[0.0001366939,0.000101001,0.0002628644,0.0001436137,0.0002144677,0.0002341014,0.0002133081,0.0005048373,0.0001866642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003992403,"about_ca_system_score_gemma":0.000198852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005624437,"about_ca_topic_score_gemma":0.0007271674,"domain_scores_codex":[0.9998958,0.00001264083,0.00001171762,0.00002391712,0.00002550472,0.000030382],"domain_scores_gemma":[0.9999267,0.000006586833,0.00003158175,0.000006210998,0.000008185946,0.00002072203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008412091,0.0001007901,0.02096587,0.0001190603,0.0000238549,0.0003355539,0.00006706756,0.0002624727,0.9691535,0.0002120885,0.0001477509,0.007770837],"study_design_scores_gemma":[0.0001339268,0.001938246,0.4836532,0.00002784131,0.0001323055,0.004540253,0.0004804231,0.008132411,0.493455,0.0006116174,0.006861127,0.00003360792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970105,0.001660732,0.0006273525,0.00008432315,0.000007356903,0.0000100131,0.0001640519,0.00004120122,0.0003945151],"genre_scores_gemma":[0.9988692,0.0003339648,0.0002164843,0.00002547401,0.000002960855,0.00001245525,0.0001584183,0.000003016752,0.0003779415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001118123,"threshold_uncertainty_score":0.003740489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090085583676747,"score_gpt":0.2458138834795271,"score_spread":0.2349130276427596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}