{"id":"W4410927250","doi":"10.1056/nejmoa2502929","title":"First-Line Camizestrant for Emerging <i>ESR1</i> -Mutated Advanced Breast Cancer","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Agence Nationale de la Recherche; AstraZeneca","keywords":"Breast cancer; Line (geometry); Oncology; Cancer research; Cancer; Computational biology; Medicine; Biology; Internal medicine; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003617863,0.0002210306,0.0005611131,0.0001477547,0.0001577072,0.0002247978,0.0002150989,0.000213633,0.004675095],"category_scores_gemma":[0.0005407193,0.00006081304,0.000461882,0.000140004,0.0001646935,0.0001606297,0.0001061916,0.0004715758,0.0003977113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000454555,"about_ca_system_score_gemma":0.0003600495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002760073,"about_ca_topic_score_gemma":0.001427972,"domain_scores_codex":[0.9998794,0.00003551805,0.00001139863,0.00002334118,0.00002568487,0.00002472171],"domain_scores_gemma":[0.9997001,0.00008512352,0.000107784,0.00001693131,0.00001519271,0.00007506482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1669811,0.003876996,0.1339026,0.001820525,0.001596072,0.001457726,0.0002351677,0.001974765,0.05077161,0.0008509623,0.008093888,0.6284386],"study_design_scores_gemma":[0.1196194,0.1871035,0.5539659,0.0007038238,0.002923019,0.01343561,0.0003854993,0.003335795,0.04751264,0.001823877,0.06911819,0.00007265164],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885762,0.006874372,0.0004212945,0.0002810674,0.00008156535,0.0002676614,0.0004694402,0.00003091593,0.002997553],"genre_scores_gemma":[0.99557,0.001796663,0.0004893109,0.0002715132,0.0000769542,0.0001435043,0.0006742825,0.000004993354,0.0009728864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004675095,"threshold_uncertainty_score":0.01563972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01292950396255306,"score_gpt":0.3241416641217435,"score_spread":0.3112121601591905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}