{"id":"W4410930213","doi":"10.1172/jci187490","title":"PROX1 is an early driver of lineage plasticity in prostate cancer","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Institute for Prostate Cancer Research; Terry Fox Research Institute; National Cancer Institute; National Institutes of Health; BC Cancer Foundation; Prostate Cancer Foundation","keywords":"Prostate cancer; Lineage (genetic); Prostate; Plasticity; Biology; Cancer research; Cancer; Internal medicine; Medicine; Oncology; Genetics; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174524,0.000173772,0.0001764907,0.0002872638,0.0002434874,0.0004258881,0.000122368,0.0001337281,0.001274282],"category_scores_gemma":[0.0001201865,0.0001645484,0.0001426091,0.000231984,0.0001907119,0.0002707439,0.0002879523,0.0004974121,0.0002310493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003462076,"about_ca_system_score_gemma":0.0003836332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0010298,"about_ca_topic_score_gemma":0.002165083,"domain_scores_codex":[0.9998894,0.00001234516,0.000005136776,0.00002220246,0.00004628256,0.00002467716],"domain_scores_gemma":[0.9999315,0.000008165556,0.00002031702,0.000005636106,0.00001004184,0.00002450956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001453491,0.0000137721,0.003300873,0.0000735603,0.000008042553,0.00007110811,0.00003479342,0.0002008643,0.9888404,0.0004782417,0.0001161557,0.006716804],"study_design_scores_gemma":[0.00001375232,0.0004105456,0.07818407,0.00001679826,0.00004242337,0.0009173918,0.0001406364,0.002163179,0.9029293,0.0002851781,0.01487769,0.00001896344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829321,0.006202828,0.006430712,0.0002241915,0.00002205988,0.00006078604,0.0008659809,0.0001398029,0.003121506],"genre_scores_gemma":[0.9936463,0.002051062,0.001747505,0.00005191535,0.000008779325,0.00001785859,0.0005375835,0.00001526709,0.001923801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274282,"threshold_uncertainty_score":0.004262924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1179464176764656,"score_gpt":0.4652361321358967,"score_spread":0.3472897144594311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}