{"id":"W4410938554","doi":"10.1101/2025.05.30.657104","title":"A Catalytically Inactive Protein Kinase C alpha Mutation Drives Chordoid Glioma by Pathway Rewiring","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Tiroler Wissenschaftsförderung; Sorbonne Université; Direction Générale de l’offre de Soins; National Institutes of Health; Institut National Du Cancer; University of California, San Diego; Ligue Contre le Cancer; Pharmaceutical Research and Manufacturers of America Foundation; Austrian Science Fund; Government of Ontario; Institut National de la Santé et de la Recherche Médicale","keywords":"Interactome; Protein kinase C; Immunoprecipitation; Scaffold protein; Mutant; Cell biology; Mutation; Phosphorylation; Biology; Kinase; Signal transduction; Chemistry; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009070832,0.0003077255,0.0001450018,0.0002366675,0.0001389689,0.000229531,0.0001950875,0.0002567899,0.001386129],"category_scores_gemma":[0.0001191136,0.00008959258,0.0001869181,0.0001427693,0.0003383402,0.00007147624,0.000204925,0.0005240948,0.0004435223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003718776,"about_ca_system_score_gemma":0.0002024596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008886444,"about_ca_topic_score_gemma":0.000892514,"domain_scores_codex":[0.9998825,0.00001753027,0.00001394158,0.00002945275,0.00003174468,0.0000248697],"domain_scores_gemma":[0.9998186,0.00003793334,0.00005165176,0.00002529065,0.000008415296,0.00005813941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006889431,0.00001424038,0.0004716309,0.00001376709,0.000005185941,0.0005431271,0.000009533767,0.00007731663,0.9979025,0.0001782979,0.00006260532,0.0006528473],"study_design_scores_gemma":[0.00002723214,0.0001239577,0.006769283,0.000005142834,0.00001260116,0.002989834,0.00005083556,0.001777444,0.9856725,0.0001461268,0.002419963,0.000005087812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974849,0.0001301117,0.001061787,0.00009423033,0.00002964394,0.00001371145,0.0004047372,0.00005867569,0.0007221987],"genre_scores_gemma":[0.9980508,0.00006373061,0.0006892348,0.00002769143,0.000005653139,0.000006097968,0.0002277812,0.00001691993,0.0009119838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001386129,"threshold_uncertainty_score":0.004637063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007601986620986701,"score_gpt":0.220084770402027,"score_spread":0.2124827837810403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}